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10.1038/ncomms7623 http://scihub22266oqcxt.onion/10.1038/ncomms7623 C4389244!4389244!25818172     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun ä ; 6 (ä): ä Nephropedia Template TP {{tp|p=25818172|t=ä. Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice |pdf=|usr=}}{{25818172}} gab.com Text Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25818172 #FOAvip Mice exposed to standard (SE) or enriched environment (EE) were transplanted with murine or human glioma cells and differences in tumour development were evaluated. We report that EE exposure affects: (i) tumour size, increasing mice survival; (ii) glioma establishment, proliferation and invasion; (iii) microglia/macrophage (M/M?) activation; (iv) natural killer (NK) cell infiltration and activation; and (v) cerebral levels of IL-15 and BDNF. Direct infusion of IL-15 or BDNF in the brain of mice transplanted with glioma significantly reduces tumour growth. We demonstrate that brain infusion of IL-15 increases the frequency of NK cell infiltrating the tumour and that NK cell depletion reduces the efficacy of EE and IL-15 on tumour size and of EE on mice survival. BDNF infusion reduces M/M? infiltration and CD68 immunoreactivity in tumour mass and reduces glioma migration inhibiting the small G protein RhoA through the truncated TrkB.T1 receptor. These results suggest alternative approaches for glioma treatment. Twit Text FOAVip Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25818172 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25818172 #FOAvip English Wikipedia <ref>{{Cite pmid|25818172}}</ref> Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice #MMPMID25818172 Garofalo S; D?Alessandro G; Chece G; Brau F; Maggi L; Rosa A; Porzia A; Mainiero F; Esposito V; Lauro C; Benigni G; Bernardini G; Santoni A; Limatola C Nat Commun ä[]; 6 (ä): ä PMID25818172show ga Mice exposed to standard (SE) or enriched environment (EE) were transplanted with murine or human glioma cells and differences in tumour development were evaluated. We report that EE exposure affects: (i) tumour size, increasing mice survival; (ii) glioma establishment, proliferation and invasion; (iii) microglia/macrophage (M/M?) activation; (iv) natural killer (NK) cell infiltration and activation; and (v) cerebral levels of IL-15 and BDNF. Direct infusion of IL-15 or BDNF in the brain of mice transplanted with glioma significantly reduces tumour growth. We demonstrate that brain infusion of IL-15 increases the frequency of NK cell infiltrating the tumour and that NK cell depletion reduces the efficacy of EE and IL-15 on tumour size and of EE on mice survival. BDNF infusion reduces M/M? infiltration and CD68 immunoreactivity in tumour mass and reduces glioma migration inhibiting the small G protein RhoA through the truncated TrkB.T1 receptor. These results suggest alternative approaches for glioma treatment. äEnriched environment reduces glioma growth through immune and non-immu(epmc).pdf DeepDyve Pubget Overpricing