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10.1093/ckj/sft130

http://scihub22266oqcxt.onion/10.1093/ckj/sft130
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C4389153!4389153!25859344
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suck abstract from ncbi


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pmid25859344      Clin+Kidney+J 2014 ; 7 (1): 3-10
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  • Endovascular renal denervation: a novel sympatholytic with relevance to chronic kidney disease #MMPMID25859344
  • Hoye NA; Baldi JC; Putt TL; Schollum JB; Wilkins GT; Walker RJ
  • Clin Kidney J 2014[Feb]; 7 (1): 3-10 PMID25859344show ga
  • Endovascular renal denervation (sympathectomy) is a novel procedure developed for the treatment of resistant hypertension. Evidence suggests that it reduces both afferent and efferent sympathetic nerve activity, which may offer clinical benefit over and above any blood pressure-lowering effect. Studies have shown objective improvements in left ventricular mass, ventricular function, central arterial stiffness, central haemodynamics, baroreflex sensitivity and arrhythmia frequency. Benefits have also been seen in insulin resistance, microalbuminuria and glomerular filtration rate. In chronic kidney disease, elevated sympathetic activity has been causally linked to disease progression and cardiovascular sequelae. Effecting a marked reduction in sympathetic hyperactivity may herald a significant step in the management of this and other conditions. In this in-depth review, the pathophysiology and clinical significance of the sympatholytic effects of endovascular renal denervation are discussed.
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