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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Neurology
2015 ; 84
(13
): 1369-78
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Evidence-based guideline summary: evaluation, diagnosis, and management of
congenital muscular dystrophy: Report of the Guideline Development Subcommittee
of the American Academy of Neurology and the Practice Issues Review Panel of the
American Association of Neuromuscular & Electrodiagnostic Medicine
#MMPMID25825463
Kang PB
; Morrison L
; Iannaccone ST
; Graham RJ
; Bönnemann CG
; Rutkowski A
; Hornyak J
; Wang CH
; North K
; Oskoui M
; Getchius TS
; Cox JA
; Hagen EE
; Gronseth G
; Griggs RC
Neurology
2015[Mar]; 84
(13
): 1369-78
PMID25825463
show ga
OBJECTIVE: To delineate optimal diagnostic and therapeutic approaches to
congenital muscular dystrophy (CMD) through a systematic review and analysis of
the currently available literature. METHODS: Relevant, peer-reviewed research
articles were identified using a literature search of the MEDLINE, EMBASE, and
Scopus databases. Diagnostic and therapeutic data from these articles were
extracted and analyzed in accordance with the American Academy of Neurology
classification of evidence schemes for diagnostic, prognostic, and therapeutic
studies. Recommendations were linked to the strength of the evidence, other
related literature, and general principles of care. RESULTS: The geographic and
ethnic backgrounds, clinical features, brain imaging studies, muscle imaging
studies, and muscle biopsies of children with suspected CMD help predict
subtype-specific diagnoses. Genetic testing can confirm some subtype-specific
diagnoses, but not all causative genes for CMD have been described. Seizures and
respiratory complications occur in specific subtypes. There is insufficient
evidence to determine the efficacy of various treatment interventions to optimize
respiratory, orthopedic, and nutritional outcomes, and more data are needed
regarding complications. RECOMMENDATIONS: Multidisciplinary care by experienced
teams is important for diagnosing and promoting the health of children with CMD.
Accurate assessment of clinical presentations and genetic data will help in
identifying the correct subtype-specific diagnosis in many cases. Multiorgan
system complications occur frequently; surveillance and prompt interventions are
likely to be beneficial for affected children. More research is needed to fill
gaps in knowledge regarding this category of muscular dystrophies.