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10.1371/journal.pone.0122904 http://scihub22266oqcxt.onion/10.1371/journal.pone.0122904 C4388661!4388661 !25849372     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25849372 &cmd=llinks): Failed to open stream: HTTP request failed! 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Apolipoprotein-A1 as a damage-associated molecular patterns protein in osteoarthritis: ex vivo and in vitro pro-inflammatory properties |pdf=|usr=}}{{25849372 }} gab.com Text Apolipoprotein-A1 as a damage-associated molecular patterns protein in osteoarthritis: ex vivo and in vitro pro-inflammatory properties JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=25849372 #FOAvip Osteoarthritis (OA) is associated with a local inflammatory process. Dyslipidemia is known to be an underlying cause for the development of OA. Therefore, lipid and inflammatory levels were quantified ex vivo in blood and synovial fluid of OA patients (n=29) and compared to those of rheumatoid arthritis (RA) patients (n=27) or healthy volunteers (HV) (n=35). The role of apolipoprotein A-I (ApoA1) was investigated in vitro on inflammatory parameters using human joint cells isolated from cartilage and synovial membrane obtained from OA patients after joint replacement. Cells were stimulated with ApoA1 in the presence or not of serum amyloid A (SAA) protein and/or lipoproteins (LDL and HDL) at physiological concentration observed in OA synovial fluid. In our ex vivo study, ApoA1, LDL-C and total cholesterol levels were strongly correlated to each other inside the OA joint cavity whereas same levels were not or weakly correlated to their corresponding serum levels. In OA synovial fluid, ApoA1 was not as strongly correlated to HDL as observed in OA serum or in RA synovial fluid, suggesting a dissociative level between ApoA1 and HDL in OA synovial fluid. In vitro, ApoA1 induced IL-6, MMP-1 and MMP-3 expression by primary chondrocytes and fibroblast-like synoviocytes through TLR4 receptor. HDL and LDL attenuated joint inflammatory response induced by ApoA1 and SAA in a ratio dependent manner. In conclusion, a dysregulated lipidic profile in the synovial fluid of OA patients was observed and was correlated with inflammatory parameters in the OA joint cavity. Pro-inflammatory properties of ApoA1 were confirmed in vitro. Twit Text FOAVip Apolipoprotein-A1 as a damage-associated molecular patterns protein in osteoarthritis: ex vivo and in vitro pro-inflammatory properties ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=25849372 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25849372 #FOAvip English Wikipedia <ref>{{Cite pmid|25849372 }}</ref> Apolipoprotein-A1 as a damage-associated molecular patterns protein in osteoarthritis: ex vivo and in vitro pro-inflammatory properties #MMPMID25849372 de Seny D ; Cobraiville G ; Charlier E ; Neuville S ; Lutteri L ; Le Goff C ; Malaise D ; Malaise O ; Chapelle JP ; Relic B ; Malaise MG PLoS One 2015[]; 10 (4 ): e0122904 PMID25849372 show ga Osteoarthritis (OA) is associated with a local inflammatory process. Dyslipidemia is known to be an underlying cause for the development of OA. Therefore, lipid and inflammatory levels were quantified ex vivo in blood and synovial fluid of OA patients (n=29) and compared to those of rheumatoid arthritis (RA) patients (n=27) or healthy volunteers (HV) (n=35). The role of apolipoprotein A-I (ApoA1) was investigated in vitro on inflammatory parameters using human joint cells isolated from cartilage and synovial membrane obtained from OA patients after joint replacement. Cells were stimulated with ApoA1 in the presence or not of serum amyloid A (SAA) protein and/or lipoproteins (LDL and HDL) at physiological concentration observed in OA synovial fluid. In our ex vivo study, ApoA1, LDL-C and total cholesterol levels were strongly correlated to each other inside the OA joint cavity whereas same levels were not or weakly correlated to their corresponding serum levels. In OA synovial fluid, ApoA1 was not as strongly correlated to HDL as observed in OA serum or in RA synovial fluid, suggesting a dissociative level between ApoA1 and HDL in OA synovial fluid. In vitro, ApoA1 induced IL-6, MMP-1 and MMP-3 expression by primary chondrocytes and fibroblast-like synoviocytes through TLR4 receptor. HDL and LDL attenuated joint inflammatory response induced by ApoA1 and SAA in a ratio dependent manner. In conclusion, a dysregulated lipidic profile in the synovial fluid of OA patients was observed and was correlated with inflammatory parameters in the OA joint cavity. Pro-inflammatory properties of ApoA1 were confirmed in vitro. |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Apolipoprotein A-I/*metabolism [MESH] |Cells, Cultured [MESH] |Chondrocytes/immunology/metabolism [MESH] |Female [MESH] |Humans [MESH] |Interleukin-6/genetics/metabolism [MESH] |Lipopolysaccharides/pharmacology [MESH] |Male [MESH] |Matrix Metalloproteinase 1/metabolism [MESH] |Matrix Metalloproteinase 3/metabolism [MESH] |Middle Aged [MESH] |Osteoarthritis/immunology/*metabolism [MESH] |Primary Cell Culture [MESH] |Synovial Fluid/metabolism [MESH] |Toll-Like Receptor 4/metabolism [MESH] |Transcriptional Activation [MESH]Apolipoprotein-A1 as a damage-associated molecular patterns protein in(epmc).pdf DeepDyve Pubget Overpricing