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10.3389/fimmu.2015.00138

http://scihub22266oqcxt.onion/10.3389/fimmu.2015.00138
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C4387933!4387933!25904912
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suck abstract from ncbi


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pmid25904912      Front+Immunol 2015 ; 6 (ä): ä
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  • Protein Microarrays: A New Tool for the Study of Autoantibodies in Immunodeficiency #MMPMID25904912
  • Rosenberg JM; Utz PJ
  • Front Immunol 2015[]; 6 (ä): ä PMID25904912show ga
  • Autoimmunity is highly coincident with immunodeficiency. In a small but growing number of primary immunodeficiencies, autoantibodies are diagnostic of a given disease and implicated in disease pathogenesis. In order to improve our understanding of the role of autoantibodies in immunodeficiencies and to discover novel autoantibodies, new proteomic tools are needed. Protein microarrays have the ability to screen for reactivity to hundreds to many thousands of unique autoantigens simultaneously on a single chip using minimal serum input. Here, we review different types of protein microarrays and how they can be useful in framing the study of primary and secondary immunodeficiencies.
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