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10.1016/j.lfs.2014.03.028 http://scihub22266oqcxt.onion/10.1016/j.lfs.2014.03.028 C4387882!4387882 !24721511     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24721511 &cmd=llinks): Failed to open stream: HTTP request failed! 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Tissue-specific and time-dependent regulation of the endothelin axis by the circadian clock protein Per1 |pdf=|usr=}}{{24721511 }} gab.com Text Tissue-specific and time-dependent regulation of the endothelin axis by the circadian clock protein Per1 JO: Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=24721511 #FOAvip AIMS: The present study is designed to consider a role for the circadian clock protein Per1 in the regulation of the endothelin axis in mouse kidney, lung, liver and heart. Renal endothelin-1 (ET-1) is a regulator of the epithelial sodium channel (ENaC) and blood pressure (BP), via activation of both endothelin receptors, ETA and ETB. However, ET-1 mediates many complex events in other tissues. MAIN METHODS: Tissues were collected in the middle of murine rest and active phases, at noon and midnight, respectively. ET-1, ETA and ETB mRNA expressions were measured in the lung, heart, liver, renal inner medulla and renal cortex of wild type and Per1 heterozygous mice using real-time quantitative RT-PCR. KEY FINDINGS: The effect of reduced Per1 expression on levels of mRNAs and the time-dependent regulation of expression of the endothelin axis genes appeared to be tissue-specific. In the renal inner medulla and the liver, ETA and ETB exhibited peaks of expression in opposite circadian phases. In contrast, expressions of ET-1, ETA and ETB in the lung did not appear to vary with time, but ET-1 expression was dramatically decreased in this tissue in Per1 heterozygous mice. Interestingly, ET-1 and ETA, but not ETB, were expressed in a time-dependent manner in the heart. SIGNIFICANCE: Per1 appears to regulate expression of the endothelin axis genes in a tissue-specific and time-dependent manner. These observations have important implications for our understanding of the best time of day to deliver endothelin receptor antagonists. Twit Text FOAVip Tissue-specific and time-dependent regulation of the endothelin axis by the circadian clock protein Per1 ????Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=24721511 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24721511 #FOAvip English Wikipedia <ref>{{Cite pmid|24721511 }}</ref> Tissue-specific and time-dependent regulation of the endothelin axis by the circadian clock protein Per1 #MMPMID24721511 Richards J ; Welch AK ; Barilovits SJ ; All S ; Cheng KY ; Wingo CS ; Cain BD ; Gumz ML Life Sci 2014[Nov]; 118 (2 ): 255-62 PMID24721511 show ga AIMS: The present study is designed to consider a role for the circadian clock protein Per1 in the regulation of the endothelin axis in mouse kidney, lung, liver and heart. Renal endothelin-1 (ET-1) is a regulator of the epithelial sodium channel (ENaC) and blood pressure (BP), via activation of both endothelin receptors, ETA and ETB. However, ET-1 mediates many complex events in other tissues. MAIN METHODS: Tissues were collected in the middle of murine rest and active phases, at noon and midnight, respectively. ET-1, ETA and ETB mRNA expressions were measured in the lung, heart, liver, renal inner medulla and renal cortex of wild type and Per1 heterozygous mice using real-time quantitative RT-PCR. KEY FINDINGS: The effect of reduced Per1 expression on levels of mRNAs and the time-dependent regulation of expression of the endothelin axis genes appeared to be tissue-specific. In the renal inner medulla and the liver, ETA and ETB exhibited peaks of expression in opposite circadian phases. In contrast, expressions of ET-1, ETA and ETB in the lung did not appear to vary with time, but ET-1 expression was dramatically decreased in this tissue in Per1 heterozygous mice. Interestingly, ET-1 and ETA, but not ETB, were expressed in a time-dependent manner in the heart. SIGNIFICANCE: Per1 appears to regulate expression of the endothelin axis genes in a tissue-specific and time-dependent manner. These observations have important implications for our understanding of the best time of day to deliver endothelin receptor antagonists. |*Circadian Clocks/genetics [MESH] |*Organ Specificity/genetics [MESH] |Animals [MESH] |Endothelin-1/metabolism [MESH] |Endothelins/*metabolism [MESH] |Gene Expression Profiling [MESH] |Gene Expression Regulation [MESH] |Kidney/metabolism [MESH] |Mice [MESH] |Period Circadian Proteins/*metabolism [MESH] |RNA, Messenger/genetics/metabolism [MESH] |Receptor, Endothelin A/metabolism [MESH] |Receptor, Endothelin B/metabolism [MESH]Tissue-specific and time-dependent regulation of the endothelin axis b(epmc).pdf DeepDyve Pubget Overpricing