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10.1038/cr.2015.33 http://scihub22266oqcxt.onion/10.1038/cr.2015.33 C4387561!4387561 !25793315     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25793315 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25793315 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Res 2015 ; 25 (4 ): 429-44 Nephropedia Template TP {{tp|p=25793315 |t=2015. cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions |pdf=|usr=}}{{25793315 }} gab.com Text cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions JO: Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=25793315 #FOAvip Cancer cells are known to undergo metabolic reprogramming to sustain survival and rapid proliferation, however, it remains to be fully elucidated how oncogenic lesions coordinate the metabolic switch under various stressed conditions. Here we show that deprivation of glucose or glutamine, two major nutrition sources for cancer cells, dramatically activated serine biosynthesis pathway (SSP) that was accompanied by elevated cMyc expression. We further identified that cMyc stimulated SSP activation by transcriptionally upregulating expression of multiple SSP enzymes. Moreover, we demonstrated that SSP activation facilitated by cMyc led to elevated glutathione (GSH) production, cell cycle progression and nucleic acid synthesis, which are essential for cell survival and proliferation especially under nutrient-deprived conditions. We further uncovered that phosphoserine phosphatase (PSPH), the final rate-limiting enzyme of the SSP pathway, is critical for cMyc-driven cancer progression both in vitro and in vivo, and importantly, aberrant expression of PSPH is highly correlated with mortality in hepatocellular carcinoma (HCC) patients, suggesting a potential causal relation between this cMyc-regulated enzyme, or SSP activation in general, and cancer development. Taken together, our results reveal that aberrant expression of cMyc leads to the enhanced SSP activation, an essential part of metabolic switch, to facilitate cancer progression under nutrient-deprived conditions. Twit Text FOAVip cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions ????Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=25793315 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25793315 #FOAvip English Wikipedia <ref>{{Cite pmid|25793315 }}</ref> cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions #MMPMID25793315 Sun L ; Song L ; Wan Q ; Wu G ; Li X ; Wang Y ; Wang J ; Liu Z ; Zhong X ; He X ; Shen S ; Pan X ; Li A ; Wang Y ; Gao P ; Tang H ; Zhang H Cell Res 2015[Apr]; 25 (4 ): 429-44 PMID25793315 show ga Cancer cells are known to undergo metabolic reprogramming to sustain survival and rapid proliferation, however, it remains to be fully elucidated how oncogenic lesions coordinate the metabolic switch under various stressed conditions. Here we show that deprivation of glucose or glutamine, two major nutrition sources for cancer cells, dramatically activated serine biosynthesis pathway (SSP) that was accompanied by elevated cMyc expression. We further identified that cMyc stimulated SSP activation by transcriptionally upregulating expression of multiple SSP enzymes. Moreover, we demonstrated that SSP activation facilitated by cMyc led to elevated glutathione (GSH) production, cell cycle progression and nucleic acid synthesis, which are essential for cell survival and proliferation especially under nutrient-deprived conditions. We further uncovered that phosphoserine phosphatase (PSPH), the final rate-limiting enzyme of the SSP pathway, is critical for cMyc-driven cancer progression both in vitro and in vivo, and importantly, aberrant expression of PSPH is highly correlated with mortality in hepatocellular carcinoma (HCC) patients, suggesting a potential causal relation between this cMyc-regulated enzyme, or SSP activation in general, and cancer development. Taken together, our results reveal that aberrant expression of cMyc leads to the enhanced SSP activation, an essential part of metabolic switch, to facilitate cancer progression under nutrient-deprived conditions. |Animals [MESH] |Apoptosis/genetics [MESH] |Carcinoma, Hepatocellular/enzymology/*metabolism/pathology [MESH] |Cell Proliferation/genetics [MESH] |Food Deprivation [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Glutathione/biosynthesis [MESH] |Humans [MESH] |Liver Neoplasms/enzymology/*metabolism/pathology [MESH] |Metabolic Networks and Pathways/genetics [MESH] |Mice [MESH] |Phosphoric Monoester Hydrolases/*biosynthesis/genetics [MESH] |Proto-Oncogene Proteins c-myc/*biosynthesis/genetics [MESH] |Serine/biosynthesis/genetics [MESH]cMyc-mediated activation of serine biosynthesis pathway is critical fo(epmc).pdf DeepDyve Pubget Overpricing