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10.1038/nrm3565 http://scihub22266oqcxt.onion/10.1038/nrm3565 C4387238!4387238!23609508     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Mol+Cell+Biol 2013 ; 14 (5): 283-96 Nephropedia Template TP {{tp|p=23609508|t=2013. Signals for the lysosome: a control center for cellular clearance and energy metabolism |pdf=|usr=}}{{23609508}} gab.com Text Signals for the lysosome: a control center for cellular clearance and energy metabolism JO: Nat Rev Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=23609508 #FOAvip For a long time lysosomes were considered merely to be cellular ?incinerators? involved in the degradation and recycling of cellular waste. However, there is now compelling evidence indicating that lysosomes have a much broader function and that they are involved in fundamental processes such as secretion, plasma membrane repair, signaling and energy metabolism. Furthermore, the essential role of lysosomes in the autophagic pathway puts these organelles at the crossroads of several cellular processes, with significant implications for health and disease. The identification of a master gene, transcription factor EB (TFEB), that regulates lysosomal biogenesis and autophagy, has revealed how the lysosome adapts to environmental cues, such as starvation, and suggests novel therapeutic strategies for modulating lysosomal function in human disease. Twit Text FOAVip Signals for the lysosome: a control center for cellular clearance and energy metabolism ????Nat Rev Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=23609508 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23609508 #FOAvip English Wikipedia <ref>{{Cite pmid|23609508}}</ref> Signals for the lysosome: a control center for cellular clearance and energy metabolism #MMPMID23609508 Settembre C; Fraldi A; Medina DL; Ballabio A Nat Rev Mol Cell Biol 2013[May]; 14 (5): 283-96 PMID23609508show ga For a long time lysosomes were considered merely to be cellular ?incinerators? involved in the degradation and recycling of cellular waste. However, there is now compelling evidence indicating that lysosomes have a much broader function and that they are involved in fundamental processes such as secretion, plasma membrane repair, signaling and energy metabolism. Furthermore, the essential role of lysosomes in the autophagic pathway puts these organelles at the crossroads of several cellular processes, with significant implications for health and disease. The identification of a master gene, transcription factor EB (TFEB), that regulates lysosomal biogenesis and autophagy, has revealed how the lysosome adapts to environmental cues, such as starvation, and suggests novel therapeutic strategies for modulating lysosomal function in human disease. äSignals for the lysosome: a control center for cellular clearance and (epmc).pdf DeepDyve Pubget Overpricing