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10.1097/MNH.0000000000000078 http://scihub22266oqcxt.onion/10.1097/MNH.0000000000000078 C4386894!4386894!25415617     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Nephrol+Hypertens 2015 ; 24 (1): 104-10 Nephropedia Template TP {{tp|p=25415617|t=2015. Insulin signaling: implications for podocyte biology in diabetic kidney disease |pdf=|usr=}}{{25415617}} gab.com Text Insulin signaling: implications for podocyte biology in diabetic kidney disease JO: Curr Opin Nephrol Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=25415617 #FOAvip Purpose of review: Several key elements of the insulin signaling cascade contribute to podocyte function and survival. While it was initially thought that the consequences of altered insulin signaling to podocyte function was strictly related to altered glucose uptake, it has become clear that upstream signaling events involved in cell survival, lipid metabolism or nutrient sensing and modulated by insulin are strong independent contributors to podocyte function. Recent findings: Akt2, the major isoform of Akt activated following cellular insulin stimulation, protects against the progression of renal disease in nephron-deficient mice, and podocyte-specific deletion of Akt2 results in a more rapid progression of experimental glomerular disease. In diabetes, podocyte mammalian target of rapamycin activation clearly contributes to podocyte injury and regulated autophagy. Furthermore, podocyte-specific glucose transporter type 4 (GLUT4) deficiency protects podocytes by preventing mammalian target of rapamycin signaling independently of glucose uptake. Finally, intracellular lipids have been recently recognized as major modulators of podocyte insulin signaling and as a new therapeutic target. Summary: The identification of new contributors to podocyte insulin signaling is of extreme translational value as it may lead to new drug development strategies for diabetic kidney disease, as well as for other proteinuric kidney diseases. Twit Text FOAVip Insulin signaling: implications for podocyte biology in diabetic kidney disease ????Curr Opin Nephrol Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=25415617 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25415617 #FOAvip English Wikipedia <ref>{{Cite pmid|25415617}}</ref> Insulin signaling: implications for podocyte biology in diabetic kidney disease #MMPMID25415617 Coward R; Fornoni A Curr Opin Nephrol Hypertens 2015[Jan]; 24 (1): 104-10 PMID25415617show ga Purpose of review: Several key elements of the insulin signaling cascade contribute to podocyte function and survival. While it was initially thought that the consequences of altered insulin signaling to podocyte function was strictly related to altered glucose uptake, it has become clear that upstream signaling events involved in cell survival, lipid metabolism or nutrient sensing and modulated by insulin are strong independent contributors to podocyte function. Recent findings: Akt2, the major isoform of Akt activated following cellular insulin stimulation, protects against the progression of renal disease in nephron-deficient mice, and podocyte-specific deletion of Akt2 results in a more rapid progression of experimental glomerular disease. In diabetes, podocyte mammalian target of rapamycin activation clearly contributes to podocyte injury and regulated autophagy. Furthermore, podocyte-specific glucose transporter type 4 (GLUT4) deficiency protects podocytes by preventing mammalian target of rapamycin signaling independently of glucose uptake. Finally, intracellular lipids have been recently recognized as major modulators of podocyte insulin signaling and as a new therapeutic target. Summary: The identification of new contributors to podocyte insulin signaling is of extreme translational value as it may lead to new drug development strategies for diabetic kidney disease, as well as for other proteinuric kidney diseases. äInsulin signaling: implications for podocyte biology in diabetic kidne(epmc).pdf DeepDyve Pubget Overpricing