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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Nat+Rev+Cancer 2013 ; 13 (6): 397-411 Nephropedia Template TP
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Neuroblastoma: Developmental Biology, Cancer Genomics, and Immunotherapy #MMPMID23702928
Cheung NKV; Dyer MA
Nat Rev Cancer 2013[Jun]; 13 (6): 397-411 PMID23702928show ga
Neuroblastoma is a solid tumor that arises from the developing sympathetic nervous system. Over the past decade, our understanding of this disease has advanced tremendously. The future challenge is to apply the knowledge gained toward developing risk-based therapies and ultimately improving outcome. Here we review the key discoveries in the developmental biology, molecular genetics, and immunology of neuroblastoma, as well as new translational tools to bring these promising scientific advances into the clinic.