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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (13): 4098-103 Nephropedia Template TP
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Molecular ruler determines needle length for the Salmonella Spi-1 injectisome #MMPMID25775540
Wee DH; Hughes KT
Proc Natl Acad Sci U S A 2015[Mar]; 112 (13): 4098-103 PMID25775540show ga
Type-III secretion systems facilitate the virulence capability of Gram-negative bacterial pathogens. They are part of complex nanomachines that include the bacterial flagellum, which confers motility, and the injectisome, which secretes proteins from the infecting bacterial cytoplasm into eukaryotic host cells. Here we examine the mechanisms of length control for the main component of the injectisome and flagellar basal structures, the needle and the hook, respectively. The defined lengths of the hook and needle are important for their function. We find that both systems use a secreted, molecular ruler to effect length determination at the nanometer-scale. Understanding the mechanisms of length control in these systems provides insight into bacterial pathogens and a biological model for the controlled construction of nanomaterials.