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10.1073/pnas.1502850112 http://scihub22266oqcxt.onion/10.1073/pnas.1502850112 C4386353!4386353!25775582     free     free     free       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (13): 3892-7 Nephropedia Template TP {{tp|p=25775582|t=2015. Immunomodulatory spherical nucleic acids |pdf=|usr=}}{{25775582}} gab.com Text Immunomodulatory spherical nucleic acids JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25775582 #FOAvip We show that by organizing immunomodulatory nucleic acids into spherical nucleic acid (SNA) form, significant increases in activity are observed. Treatment of mice with cancer using immunostimulatory SNAs and nonalcoholic steatohepatitis (NASH) using immunoregulatory SNAs leads to improved disease outcomes vs. their unstructured counterparts. These improvements derive from several key SNA properties, including rapid cellular uptake, endosomal delivery, and multivalent binding. Overall, this work underscores the importance of the spatial orientation and presentation of oligonucleotides in the design of novel immunomodulators. Twit Text FOAVip Immunomodulatory spherical nucleic acids ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25775582 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25775582 #FOAvip English Wikipedia <ref>{{Cite pmid|25775582}}</ref> Immunomodulatory spherical nucleic acids #MMPMID25775582 Radovic-Moreno AF; Chernyak N; Mader CC; Nallagatla S; Kang RS; Hao L; Walker DA; Halo TL; Merkel TJ; Rische CH; Anantatmula S; Burkhart M; Mirkin CA; Gryaznov SM Proc Natl Acad Sci U S A 2015[Mar]; 112 (13): 3892-7 PMID25775582show ga We show that by organizing immunomodulatory nucleic acids into spherical nucleic acid (SNA) form, significant increases in activity are observed. Treatment of mice with cancer using immunostimulatory SNAs and nonalcoholic steatohepatitis (NASH) using immunoregulatory SNAs leads to improved disease outcomes vs. their unstructured counterparts. These improvements derive from several key SNA properties, including rapid cellular uptake, endosomal delivery, and multivalent binding. Overall, this work underscores the importance of the spatial orientation and presentation of oligonucleotides in the design of novel immunomodulators. äImmunomodulatory spherical nucleic acids (epmc).pdf DeepDyve Pubget Overpricing