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10.1073/pnas.1421587112 http://scihub22266oqcxt.onion/10.1073/pnas.1421587112 C4386332!4386332!25733846     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (13): E1530-9 Nephropedia Template TP {{tp|p=25733846|t=2015. TALE nickase-mediated SP110 knockin endows cattle with increased resistance to tuberculosis |pdf=|usr=}}{{25733846}} gab.com Text TALE nickase-mediated SP110 knockin endows cattle with increased resistance to tuberculosis JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25733846 #FOAvip Bovine tuberculosis is a chronic infectious disease that affects a broad range of mammalian hosts. It is a serious threat to agriculture in many less-developed countries. In this study, we introduced a mutation to the FokI of the right hand of wild-type transcription activator-like effector nuclease and established a transcription activator-like effector nickase system that creates single-strand breaks in the genome. Then we used this system to add the mouse gene SP110 to a specific location in the bovine genome and created transgenic cattle with increased resistance to tuberculosis. Our results contribute to the control and prevention of bovine tuberculosis and provide a previously unidentified insight into breeding animals for disease resistance. Twit Text FOAVip TALE nickase-mediated SP110 knockin endows cattle with increased resistance to tuberculosis ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25733846 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25733846 #FOAvip English Wikipedia <ref>{{Cite pmid|25733846}}</ref> TALE nickase-mediated SP110 knockin endows cattle with increased resistance to tuberculosis #MMPMID25733846 Wu H; Wang Y; Zhang Y; Yang M; Lv J; Liu J; Zhang Y Proc Natl Acad Sci U S A 2015[Mar]; 112 (13): E1530-9 PMID25733846show ga Bovine tuberculosis is a chronic infectious disease that affects a broad range of mammalian hosts. It is a serious threat to agriculture in many less-developed countries. In this study, we introduced a mutation to the FokI of the right hand of wild-type transcription activator-like effector nuclease and established a transcription activator-like effector nickase system that creates single-strand breaks in the genome. Then we used this system to add the mouse gene SP110 to a specific location in the bovine genome and created transgenic cattle with increased resistance to tuberculosis. Our results contribute to the control and prevention of bovine tuberculosis and provide a previously unidentified insight into breeding animals for disease resistance. äTALE nickase-mediated SP110 knockin endows cattle with increased resis(epmc).pdf DeepDyve Pubget Overpricing