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10.12669/pjms.311.5740

http://scihub22266oqcxt.onion/10.12669/pjms.311.5740
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C4386159!4386159!25878616
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suck abstract from ncbi


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pmid25878616      Pak+J+Med+Sci 2015 ; 31 (1): 65-9
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  • Detection of renal brush border membrane enzymes for evaluation of renal injury in neonatal scleredema #MMPMID25878616
  • Ren Q; Zhang Y; Yang J; Wei L; Zhao L; Yang Q
  • Pak J Med Sci 2015[Jan]; 31 (1): 65-9 PMID25878616show ga
  • Objective:: To evaluate renal brush border membrane enzymes in urine as an indicator for renal injury in neonatal scleredema (NS). Methods:: Sixty nine NS patients in our hospital were enrolled and divided into mild group and moderate/severe group. Patients were further randomly divided into therapy and control subgroups for 7 days ligustrazine administration. Urine samples were collected to detect renal brush border membrane enzymes (RBBME) by ELISA and ?2-microglobulin (?2-MG) by radioimmunoassay (RIA). The results were compared with those of 30 normal neonates. Data were statistically analyzed using SPSS13.0 software. Results:: Both RBBME and ?2-MG were found to be higher in urine in NS patients than normal controls (P < 0.01). Level of RBBME increased with the severity of NS (P <0.05), while urinary ?2-MG did not (P >0.05). After being treated with ligustrazine, a medicine for renal function recovery, both RBBME and ?2-MG were similarly significantly decreased comparing to untreated groups (P < 0.05). 79.7% of NS patients showed abnormal RBBME while only 52.2% had an abnormal urinary ?2-MG (?2=11.65?P < 0.01). Conclusion:: RBBME was more sensitive than ?2-MG in reflecting the renal injury in NS. Examination of RBBME effectively reflected the recovery of renal injury after treatment with ligustrazine.
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