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2015 ; 47
(2
): 143-7
Nephropedia Template TP
gab.com Text
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English Wikipedia
Single dose intravenous methyl prednisolone versus oral prednisolone in Bell s
palsy: a randomized controlled trial
#MMPMID25878371
Giri P
; Garg RK
; Singh MK
; Verma R
; Malhotra HS
; Sharma PK
Indian J Pharmacol
2015[Mar]; 47
(2
): 143-7
PMID25878371
show ga
OBJECTIVES: Corticosteroids have been used in the treatment of Bell's palsy and
several other postinfectious neurological conditions. We hypothesized that
administration of a single dose of intravenous (IV) methylprednisolone might be
an effective alternative to oral prednisolone. MATERIALS AND METHODS: In this
open label, randomized trial, patients with acute Bell's palsy were randomized
into two groups. One group received single dose (500 mg) of IV methylprednisolone
while the other group received 10 days of oral prednisone. Outcome was assessed
at 1 and 3 months with House-Brackmann scale. RESULTS: At 3 months, 93 (79.48%)
patients had completely recovered. IV methylprednisolone and oral prednisolone
groups had similar recovery rates (80% vs. 78.33%, P > 0.05). Patients with Grade
2 and 3 recovered completely. In patients with Grade 6, the recovery rate was
20%. A better outcome was observed if corticosteroids were administered within 3
days of onset of palsy. CONCLUSION: Intravenous methylprednisolone and oral
prednisolone showed equivalent benefit in patients with acute Bell's palsy.
|Acute Disease
[MESH]
|Administration, Oral
[MESH]
|Adult
[MESH]
|Bell Palsy/*drug therapy
[MESH]
|Drug Administration Schedule
[MESH]
|Female
[MESH]
|Glucocorticoids/*administration & dosage/therapeutic use
[MESH]
|Humans
[MESH]
|Injections, Intravenous
[MESH]
|Male
[MESH]
|Methylprednisolone/*administration & dosage/therapeutic use
[MESH]
|Prednisone/*administration & dosage/therapeutic use
[MESH]
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