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10.1038/cddis.2015.59 http://scihub22266oqcxt.onion/10.1038/cddis.2015.59 C4385937!4385937!25789970     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Dis 2015 ; 6 (3): e1695- Nephropedia Template TP {{tp|p=25789970|t=2015. IGFBP-rP1 suppresses epithelial?mesenchymal transition and metastasis in colorectal cancer |pdf=|usr=}}{{25789970}} gab.com Text IGFBP-rP1 suppresses epithelial mesenchymal transition and metastasis in colorectal cancer JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=25789970 #FOAvip Epithelial?mesenchymal transition (EMT) was initially recognized during organogenesis and has recently been reported to be involved in promoting cancer invasion and metastasis. Cooperation of transforming growth factor-? (TGF-?) and other signaling pathways, such as Ras and Wnt, is essential to inducing EMT, but the molecular mechanisms remain to be fully determined. Here, we reported that insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1), a potential tumor suppressor, controls EMT in colorectal cancer progression. We revealed the inhibitory role of IGFBP-rP1 through analyses of clinical colorectal cancer samples and various EMT and metastasis models in vitro and in vivo. Moreover, we demonstrated that IGFBP-rP1 suppresses EMT and tumor metastasis by repressing TGF-?-mediated EMT through the Smad signaling cascade. These data establish that IGFBP-rP1 functions as a suppressor of EMT and metastasis in colorectal cancer. Twit Text FOAVip IGFBP-rP1 suppresses epithelial mesenchymal transition and metastasis in colorectal cancer ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=25789970 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25789970 #FOAvip English Wikipedia <ref>{{Cite pmid|25789970}}</ref> IGFBP-rP1 suppresses epithelial?mesenchymal transition and metastasis in colorectal cancer #MMPMID25789970 Zhu S; Zhang J; Xu F; Xu E; Ruan W; Ma Y; Huang Q; Lai M Cell Death Dis 2015[Mar]; 6 (3): e1695- PMID25789970show ga Epithelial?mesenchymal transition (EMT) was initially recognized during organogenesis and has recently been reported to be involved in promoting cancer invasion and metastasis. Cooperation of transforming growth factor-? (TGF-?) and other signaling pathways, such as Ras and Wnt, is essential to inducing EMT, but the molecular mechanisms remain to be fully determined. Here, we reported that insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1), a potential tumor suppressor, controls EMT in colorectal cancer progression. We revealed the inhibitory role of IGFBP-rP1 through analyses of clinical colorectal cancer samples and various EMT and metastasis models in vitro and in vivo. Moreover, we demonstrated that IGFBP-rP1 suppresses EMT and tumor metastasis by repressing TGF-?-mediated EMT through the Smad signaling cascade. These data establish that IGFBP-rP1 functions as a suppressor of EMT and metastasis in colorectal cancer. äIGFBP-rP1 suppresses epithelial?mesenchymal transition and metastasis (epmc).pdf DeepDyve Pubget Overpricing