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10.1038/cddis.2015.39 http://scihub22266oqcxt.onion/10.1038/cddis.2015.39 C4385918!4385918 !25766322     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25766322 &cmd=llinks): Failed to open stream: HTTP request failed! 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Plasma membrane poration by opioid neuropeptides: a possible mechanism of pathological signal transduction |pdf=|usr=}}{{25766322 }} gab.com Text Plasma membrane poration by opioid neuropeptides: a possible mechanism of pathological signal transduction JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=25766322 #FOAvip Neuropeptides induce signal transduction across the plasma membrane by acting through cell-surface receptors. The dynorphins, endogenous ligands for opioid receptors, are an exception; they also produce non-receptor-mediated effects causing pain and neurodegeneration. To understand non-receptor mechanism(s), we examined interactions of dynorphins with plasma membrane. Using fluorescence correlation spectroscopy and patch-clamp electrophysiology, we demonstrate that dynorphins accumulate in the membrane and induce a continuum of transient increases in ionic conductance. This phenomenon is consistent with stochastic formation of giant (~2.7?nm estimated diameter) unstructured non-ion-selective membrane pores. The potency of dynorphins to porate the plasma membrane correlates with their pathogenic effects in cellular and animal models. Membrane poration by dynorphins may represent a mechanism of pathological signal transduction. Persistent neuronal excitation by this mechanism may lead to profound neuropathological alterations, including neurodegeneration and cell death. Twit Text FOAVip Plasma membrane poration by opioid neuropeptides: a possible mechanism of pathological signal transduction ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=25766322 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25766322 #FOAvip English Wikipedia <ref>{{Cite pmid|25766322 }}</ref> Plasma membrane poration by opioid neuropeptides: a possible mechanism of pathological signal transduction #MMPMID25766322 Maximyuk O ; Khmyz V ; Lindskog CJ ; Vukojevi? V ; Ivanova T ; Bazov I ; Hauser KF ; Bakalkin G ; Krishtal O Cell Death Dis 2015[Mar]; 6 (3 ): e1683 PMID25766322 show ga Neuropeptides induce signal transduction across the plasma membrane by acting through cell-surface receptors. The dynorphins, endogenous ligands for opioid receptors, are an exception; they also produce non-receptor-mediated effects causing pain and neurodegeneration. To understand non-receptor mechanism(s), we examined interactions of dynorphins with plasma membrane. Using fluorescence correlation spectroscopy and patch-clamp electrophysiology, we demonstrate that dynorphins accumulate in the membrane and induce a continuum of transient increases in ionic conductance. This phenomenon is consistent with stochastic formation of giant (~2.7?nm estimated diameter) unstructured non-ion-selective membrane pores. The potency of dynorphins to porate the plasma membrane correlates with their pathogenic effects in cellular and animal models. Membrane poration by dynorphins may represent a mechanism of pathological signal transduction. Persistent neuronal excitation by this mechanism may lead to profound neuropathological alterations, including neurodegeneration and cell death. |Analgesics, Opioid/administration & dosage/metabolism [MESH] |Animals [MESH] |Cell Membrane/drug effects/*metabolism [MESH] |Dynorphins/administration & dosage/metabolism [MESH] |Endorphins/administration & dosage/metabolism [MESH] |Enkephalins/genetics/*metabolism [MESH] |Humans [MESH] |Ligands [MESH] |Microscopy, Confocal [MESH] |Neuropeptides/administration & dosage/*metabolism [MESH] |Opioid Peptides/administration & dosage/*metabolism [MESH] |PC12 Cells [MESH] |Protein Precursors/genetics/*metabolism [MESH] |Rats [MESH]Plasma membrane poration by opioid neuropeptides: a possible mechanism(epmc).pdf DeepDyve Pubget Overpricing