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10.1152/ajprenal.00457.2014 http://scihub22266oqcxt.onion/10.1152/ajprenal.00457.2014 C4385886!4385886!25651565     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25651565&cmd=llinks): Failed to open stream: HTTP request failed! 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Antithrombin nanoparticles improve kidney reperfusion and protect kidney function after ischemia-reperfusion injury |pdf=|usr=}}{{25651565}} gab.com Text Antithrombin nanoparticles improve kidney reperfusion and protect kidney function after ischemia-reperfusion injury JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25651565 #FOAvip In the extension phase of acute kidney injury, microvascular thrombosis, inflammation, vasoconstriction, and vascular endothelial cell dysfunction promote progressive damage to renal parenchyma after reperfusion. In this study, we hypothesized that direct targeting and pharmaceutical knockdown of activated thrombin at the sites of injury with a selective nanoparticle (NP)-based thrombin inhibitor, PPACK (phenylalanine-proline-arginine-chloromethylketone), would improve kidney reperfusion and protect renal function after transient warm ischemia in rodent models. Saline- or plain NP-treated animals were employed as controls. In vivo 19F magnetic resonance imaging revealed that kidney nonreperfusion was evident within 3 h after global kidney reperfusion at 34 ± 13% area in the saline group and 43 ± 12% area in the plain NP group and substantially reduced to 17 ± 4% (?50% decrease, P < 0.05) in the PPACK NP pretreatment group. PPACK NP pretreatment prevented an increase in serum creatinine concentration within 24 h after ischemia-reperfusion, reflecting preserved renal function. Histologic analysis illustrated substantially reduced intrarenal thrombin accumulation within 24 h after reperfusion for PPACK NP-treated kidneys (0.11% ± 0.06%) compared with saline-treated kidneys (0.58 ± 0.37%). These results suggest a direct role for thrombin in the pathophysiology of AKI and a nanomedicine-based preventative strategy for improving kidney reperfusion after transient warm ischemia. Twit Text FOAVip Antithrombin nanoparticles improve kidney reperfusion and protect kidney function after ischemia-reperfusion injury ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25651565 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25651565 #FOAvip English Wikipedia <ref>{{Cite pmid|25651565}}</ref> Antithrombin nanoparticles improve kidney reperfusion and protect kidney function after ischemia-reperfusion injury #MMPMID25651565 Chen J; Vemuri C; Palekar RU; Gaut JP; Goette M; Hu L; Cui G; Zhang H; Wickline SA Am J Physiol Renal Physiol 2015[Apr]; 308 (7): F765-73 PMID25651565show ga In the extension phase of acute kidney injury, microvascular thrombosis, inflammation, vasoconstriction, and vascular endothelial cell dysfunction promote progressive damage to renal parenchyma after reperfusion. In this study, we hypothesized that direct targeting and pharmaceutical knockdown of activated thrombin at the sites of injury with a selective nanoparticle (NP)-based thrombin inhibitor, PPACK (phenylalanine-proline-arginine-chloromethylketone), would improve kidney reperfusion and protect renal function after transient warm ischemia in rodent models. Saline- or plain NP-treated animals were employed as controls. In vivo 19F magnetic resonance imaging revealed that kidney nonreperfusion was evident within 3 h after global kidney reperfusion at 34 ± 13% area in the saline group and 43 ± 12% area in the plain NP group and substantially reduced to 17 ± 4% (?50% decrease, P < 0.05) in the PPACK NP pretreatment group. PPACK NP pretreatment prevented an increase in serum creatinine concentration within 24 h after ischemia-reperfusion, reflecting preserved renal function. Histologic analysis illustrated substantially reduced intrarenal thrombin accumulation within 24 h after reperfusion for PPACK NP-treated kidneys (0.11% ± 0.06%) compared with saline-treated kidneys (0.58 ± 0.37%). These results suggest a direct role for thrombin in the pathophysiology of AKI and a nanomedicine-based preventative strategy for improving kidney reperfusion after transient warm ischemia. äAntithrombin nanoparticles improve kidney reperfusion and protect kidn(epmc).pdf DeepDyve Pubget Overpricing