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10.3748/wjg.v21.i13.3813 http://scihub22266oqcxt.onion/10.3748/wjg.v21.i13.3813 C4385528!4385528!25852266     free     free     free       World+J+Gastroenterol 2015 ; 21 (13): 3813-25 Nephropedia Template TP {{tp|p=25852266|t=2015. New gene therapy strategies for hepatic fibrosis |pdf=|usr=}}{{25852266}} gab.com Text New gene therapy strategies for hepatic fibrosis JO: World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=25852266 #FOAvip The liver is the largest internal organ of the body, which may suffer acute or chronic injury induced by many factors, leading to cirrhosis and hepatocarcinoma. Cirrhosis is the irreversible end result of fibrous scarring and hepatocellular regeneration, characterized by diffuse disorganization of the normal hepatic structure, regenerative nodules and fibrotic tissue. Cirrhosis is associated with a high co-morbidity and mortality without effective treatment, and much research has been aimed at developing new therapeutic strategies to guarantee recovery. Liver-based gene therapy has been used to downregulate specific genes, to block the expression of deleterious genes, to delivery therapeutic genes, to prevent allograft rejection and to augment liver regeneration. Viral and non-viral vectors have been used, with viral vectors proving to be more efficient. This review provides an overview of the main strategies used in liver-gene therapy represented by non-viral vectors, viral vectors, novel administration methods like hydrodynamic injection, hybrids of two viral vectors and blocking molecules, with the hope of translating findings from the laboratory to the patient´s bed-side. Twit Text FOAVip New gene therapy strategies for hepatic fibrosis ????World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=25852266 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25852266 #FOAvip English Wikipedia <ref>{{Cite pmid|25852266}}</ref> New gene therapy strategies for hepatic fibrosis #MMPMID25852266 Salazar-Montes AM; Hernández-Ortega LD; Lucano-Landeros MS; Armendariz-Borunda J World J Gastroenterol 2015[Apr]; 21 (13): 3813-25 PMID25852266show ga The liver is the largest internal organ of the body, which may suffer acute or chronic injury induced by many factors, leading to cirrhosis and hepatocarcinoma. Cirrhosis is the irreversible end result of fibrous scarring and hepatocellular regeneration, characterized by diffuse disorganization of the normal hepatic structure, regenerative nodules and fibrotic tissue. Cirrhosis is associated with a high co-morbidity and mortality without effective treatment, and much research has been aimed at developing new therapeutic strategies to guarantee recovery. Liver-based gene therapy has been used to downregulate specific genes, to block the expression of deleterious genes, to delivery therapeutic genes, to prevent allograft rejection and to augment liver regeneration. Viral and non-viral vectors have been used, with viral vectors proving to be more efficient. This review provides an overview of the main strategies used in liver-gene therapy represented by non-viral vectors, viral vectors, novel administration methods like hydrodynamic injection, hybrids of two viral vectors and blocking molecules, with the hope of translating findings from the laboratory to the patient´s bed-side. äNew gene therapy strategies for hepatic fibrosis (epmc).pdf DeepDyve Pubget Overpricing