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10.1083/jcb.201410095 http://scihub22266oqcxt.onion/10.1083/jcb.201410095 C4384738!4384738 !25800056     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25800056 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Biol 2015 ; 208 (7 ): 961-74 Nephropedia Template TP {{tp|p=25800056 |t=2015. WISp39 binds phosphorylated Coronin 1B to regulate Arp2/3 localization and Cofilin-dependent motility |pdf=|usr=}}{{25800056 }} gab.com Text WISp39 binds phosphorylated Coronin 1B to regulate Arp2/3 localization and Cofilin-dependent motility JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25800056 #FOAvip We previously identified Waf1 Cip1 stabilizing protein 39 (WISp39) as a binding partner for heat shock protein 90 (Hsp90). We now report that WISp39 has an essential function in the control of directed cell migration, which requires WISp39 interaction with Hsp90. WISp39 knockdown (KD) resulted in the loss of directional motility of mammalian cells and profound changes in cell morphology, including the loss of a single leading edge. WISp39 binds Coronin 1B, known to regulate the Arp2/3 complex and Cofilin at the leading edge. WISp39 preferentially interacts with phosphorylated Coronin 1B, allowing it to complex with Slingshot phosphatase (SSH) to dephosphorylate and activate Cofilin. WISp39 also regulates Arp2/3 complex localization at the leading edge. WISp39 KD-induced morphological changes could be rescued by overexpression of Coronin 1B together with a constitutively active Cofilin mutant. We conclude that WISp39 associates with Hsp90, Coronin 1B, and SSH to regulate Cofilin activation and Arp2/3 complex localization at the leading edge. Twit Text FOAVip WISp39 binds phosphorylated Coronin 1B to regulate Arp2/3 localization and Cofilin-dependent motility ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25800056 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25800056 #FOAvip English Wikipedia <ref>{{Cite pmid|25800056 }}</ref> WISp39 binds phosphorylated Coronin 1B to regulate Arp2/3 localization and Cofilin-dependent motility #MMPMID25800056 Howell M ; Brickner H ; Delorme-Walker VD ; Choi J ; Saffin JM ; Miller D ; Panopoulos A ; DerMardirossian C ; Fotedar A ; Margolis RL ; Fotedar R J Cell Biol 2015[Mar]; 208 (7 ): 961-74 PMID25800056 show ga We previously identified Waf1 Cip1 stabilizing protein 39 (WISp39) as a binding partner for heat shock protein 90 (Hsp90). We now report that WISp39 has an essential function in the control of directed cell migration, which requires WISp39 interaction with Hsp90. WISp39 knockdown (KD) resulted in the loss of directional motility of mammalian cells and profound changes in cell morphology, including the loss of a single leading edge. WISp39 binds Coronin 1B, known to regulate the Arp2/3 complex and Cofilin at the leading edge. WISp39 preferentially interacts with phosphorylated Coronin 1B, allowing it to complex with Slingshot phosphatase (SSH) to dephosphorylate and activate Cofilin. WISp39 also regulates Arp2/3 complex localization at the leading edge. WISp39 KD-induced morphological changes could be rescued by overexpression of Coronin 1B together with a constitutively active Cofilin mutant. We conclude that WISp39 associates with Hsp90, Coronin 1B, and SSH to regulate Cofilin activation and Arp2/3 complex localization at the leading edge. |Actin Depolymerizing Factors/genetics/*metabolism [MESH] |Actin-Related Protein 2-3 Complex/*metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Movement/genetics [MESH] |Enzyme Activation/genetics [MESH] |HEK293 Cells [MESH] |HSP90 Heat-Shock Proteins/metabolism [MESH] |HeLa Cells [MESH] |Humans [MESH] |Immunophilins/genetics/*metabolism [MESH] |Microfilament Proteins/biosynthesis/*metabolism [MESH] |Phosphoprotein Phosphatases [MESH] |Phosphorylation [MESH] |Protein Binding [MESH] |RNA Interference [MESH] |RNA, Small Interfering [MESH]WISp39 binds phosphorylated Coronin 1B to regulate Arp2/3 localization(epmc).pdf DeepDyve Pubget Overpricing