Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1083/jcb.201407129 http://scihub22266oqcxt.onion/10.1083/jcb.201407129 C4384732!4384732 !25825518     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25825518 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25825518 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Biol 2015 ; 208 (7 ): 987-1001 Nephropedia Template TP {{tp|p=25825518 |t=2015. CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation |pdf=|usr=}}{{25825518 }} gab.com Text CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25825518 #FOAvip Mutations in the essential adaptor proteins CCM2 or CCM3 lead to cerebral cavernous malformations (CCM), vascular lesions that most frequently occur in the brain and are strongly associated with hemorrhagic stroke, seizures, and other neurological disorders. CCM2 binds CCM3, but the molecular basis of this interaction, and its functional significance, have not been elucidated. Here, we used x-ray crystallography and structure-guided mutagenesis to show that an ?-helical LD-like motif within CCM2 binds the highly conserved "HP1" pocket of the CCM3 focal adhesion targeting (FAT) homology domain. By knocking down CCM2 or CCM3 and rescuing with binding-deficient mutants, we establish that CCM2-CCM3 interactions protect CCM2 and CCM3 proteins from proteasomal degradation and show that both CCM2 and CCM3 are required for normal endothelial cell network formation. However, CCM3 expression in the absence of CCM2 is sufficient to support normal cell growth, revealing complex-independent roles for CCM3. Twit Text FOAVip CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25825518 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25825518 #FOAvip English Wikipedia <ref>{{Cite pmid|25825518 }}</ref> CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation #MMPMID25825518 Draheim KM ; Li X ; Zhang R ; Fisher OS ; Villari G ; Boggon TJ ; Calderwood DA J Cell Biol 2015[Mar]; 208 (7 ): 987-1001 PMID25825518 show ga Mutations in the essential adaptor proteins CCM2 or CCM3 lead to cerebral cavernous malformations (CCM), vascular lesions that most frequently occur in the brain and are strongly associated with hemorrhagic stroke, seizures, and other neurological disorders. CCM2 binds CCM3, but the molecular basis of this interaction, and its functional significance, have not been elucidated. Here, we used x-ray crystallography and structure-guided mutagenesis to show that an ?-helical LD-like motif within CCM2 binds the highly conserved "HP1" pocket of the CCM3 focal adhesion targeting (FAT) homology domain. By knocking down CCM2 or CCM3 and rescuing with binding-deficient mutants, we establish that CCM2-CCM3 interactions protect CCM2 and CCM3 proteins from proteasomal degradation and show that both CCM2 and CCM3 are required for normal endothelial cell network formation. However, CCM3 expression in the absence of CCM2 is sufficient to support normal cell growth, revealing complex-independent roles for CCM3. |Apoptosis Regulatory Proteins/genetics/*metabolism/ultrastructure [MESH] |Binding Sites [MESH] |Carrier Proteins/genetics/*metabolism/ultrastructure [MESH] |Cell Line [MESH] |Cell Proliferation/*genetics [MESH] |Central Nervous System/*blood supply [MESH] |Crystallography, X-Ray [MESH] |Gene Expression [MESH] |Hemangioma, Cavernous, Central Nervous System/genetics [MESH] |Humans [MESH] |Membrane Proteins/genetics/*metabolism/ultrastructure [MESH] |Mutagenesis [MESH] |Neovascularization, Physiologic/*genetics [MESH] |Paxillin/metabolism [MESH] |Protein Binding [MESH] |Protein Interaction Mapping [MESH] |Protein Structure, Tertiary [MESH] |Proteolysis [MESH] |Proto-Oncogene Proteins/genetics/*metabolism/ultrastructure [MESH] |RNA Interference [MESH] |RNA, Small Interfering [MESH]CCM2-CCM3 interaction stabilizes their protein expression and permits (epmc).pdf DeepDyve Pubget Overpricing