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10.1083/jcb.201407131 http://scihub22266oqcxt.onion/10.1083/jcb.201407131 C4384726!4384726 !25825519     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25825519 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Biol 2015 ; 208 (7 ): 1003-18 Nephropedia Template TP {{tp|p=25825519 |t=2015. L1CAM/Neuroglian controls the axon-axon interactions establishing layered and lobular mushroom body architecture |pdf=|usr=}}{{25825519 }} gab.com Text L1CAM/Neuroglian controls the axon-axon interactions establishing layered and lobular mushroom body architecture JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25825519 #FOAvip The establishment of neuronal circuits depends on the guidance of axons both along and in between axonal populations of different identity; however, the molecular principles controlling axon-axon interactions in vivo remain largely elusive. We demonstrate that the Drosophila melanogaster L1CAM homologue Neuroglian mediates adhesion between functionally distinct mushroom body axon populations to enforce and control appropriate projections into distinct axonal layers and lobes essential for olfactory learning and memory. We addressed the regulatory mechanisms controlling homophilic Neuroglian-mediated cell adhesion by analyzing targeted mutations of extra- and intracellular Neuroglian domains in combination with cell type-specific rescue assays in vivo. We demonstrate independent and cooperative domain requirements: intercalating growth depends on homophilic adhesion mediated by extracellular Ig domains. For functional cluster formation, intracellular Ankyrin2 association is sufficient on one side of the trans-axonal complex whereas Moesin association is likely required simultaneously in both interacting axonal populations. Together, our results provide novel mechanistic insights into cell adhesion molecule-mediated axon-axon interactions that enable precise assembly of complex neuronal circuits. Twit Text FOAVip L1CAM/Neuroglian controls the axon-axon interactions establishing layered and lobular mushroom body architecture ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25825519 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25825519 #FOAvip English Wikipedia <ref>{{Cite pmid|25825519 }}</ref> L1CAM/Neuroglian controls the axon-axon interactions establishing layered and lobular mushroom body architecture #MMPMID25825519 Siegenthaler D ; Enneking EM ; Moreno E ; Pielage J J Cell Biol 2015[Mar]; 208 (7 ): 1003-18 PMID25825519 show ga The establishment of neuronal circuits depends on the guidance of axons both along and in between axonal populations of different identity; however, the molecular principles controlling axon-axon interactions in vivo remain largely elusive. We demonstrate that the Drosophila melanogaster L1CAM homologue Neuroglian mediates adhesion between functionally distinct mushroom body axon populations to enforce and control appropriate projections into distinct axonal layers and lobes essential for olfactory learning and memory. We addressed the regulatory mechanisms controlling homophilic Neuroglian-mediated cell adhesion by analyzing targeted mutations of extra- and intracellular Neuroglian domains in combination with cell type-specific rescue assays in vivo. We demonstrate independent and cooperative domain requirements: intercalating growth depends on homophilic adhesion mediated by extracellular Ig domains. For functional cluster formation, intracellular Ankyrin2 association is sufficient on one side of the trans-axonal complex whereas Moesin association is likely required simultaneously in both interacting axonal populations. Together, our results provide novel mechanistic insights into cell adhesion molecule-mediated axon-axon interactions that enable precise assembly of complex neuronal circuits. |Animals [MESH] |Ankyrins/metabolism [MESH] |Axons/physiology [MESH] |Cell Adhesion Molecules, Neuronal/*genetics [MESH] |Cell Adhesion/*genetics/physiology [MESH] |Cell Aggregation/genetics/physiology [MESH] |Cell Line [MESH] |Cerebral Peduncle/growth & development [MESH] |Drosophila Proteins/*genetics [MESH] |Drosophila melanogaster/*growth & development [MESH] |Gene Expression Regulation, Developmental [MESH] |Memory/*physiology [MESH] |Microfilament Proteins/metabolism [MESH] |Mushroom Bodies/*growth & development [MESH] |Neural Cell Adhesion Molecule L1/genetics [MESH]L1CAM/Neuroglian controls the axon-axon interactions establishing laye(epmc).pdf DeepDyve Pubget Overpricing