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2015 ; 20
(1
): 12-24
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Endocrine-disrupting Chemicals: Review of Toxicological Mechanisms Using
Molecular Pathway Analysis
#MMPMID25853100
Yang O
; Kim HL
; Weon JI
; Seo YR
J Cancer Prev
2015[Mar]; 20
(1
): 12-24
PMID25853100
show ga
Endocrine disruptors are known to cause harmful effects to human through various
exposure routes. These chemicals mainly appear to interfere with the endocrine or
hormone systems. As importantly, numerous studies have demonstrated that the
accumulation of endocrine disruptors can induce fatal disorders including obesity
and cancer. Using diverse biological tools, the potential molecular mechanisms
related with these diseases by exposure of endocrine disruptors. Recently,
pathway analysis, a bioinformatics tool, is being widely used to predict the
potential mechanism or biological network of certain chemicals. In this review,
we initially summarize the major molecular mechanisms involved in the induction
of the above mentioned diseases by endocrine disruptors. Additionally, we provide
the potential markers and signaling mechanisms discovered via pathway analysis
under exposure to representative endocrine disruptors, bisphenol,
diethylhexylphthalate, and nonylphenol. The review emphasizes the importance of
pathway analysis using bioinformatics to finding the specific mechanisms of toxic
chemicals, including endocrine disruptors.