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10.1016/j.it.2015.01.004 http://scihub22266oqcxt.onion/10.1016/j.it.2015.01.004 C4384471!4384471!25704559     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trends+Immunol 2015 ; 36 (3): 124-38 Nephropedia Template TP {{tp|p=25704559|t=2015. Interferons and viruses: an evolutionary arms race of molecular interactions |pdf=|usr=}}{{25704559}} gab.com Text Interferons and viruses: an evolutionary arms race of molecular interactions JO: Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25704559 #FOAvip Over half a century has passed since interferons (IFNs) were discovered and shown to inhibit virus infection in cultured cells. Since then, researchers have steadily brought to light the molecular details of IFN signaling, catalogued their pleiotropic effects on cells, and harnessed their therapeutic potential for a variety of maladies. While advances have been plentiful, several fundamental questions have yet to be answered and much complexity remains to be unraveled. We explore the current knowledge surrounding four main questions: are type I IFN subtypes differentially produced in response to distinct pathogens? How are IFN subtypes distinguished by cells? What are the mechanisms and consequences of viral antagonism? Lastly, how can the IFN response be harnessed to improve vaccine efficacy? Twit Text FOAVip Interferons and viruses: an evolutionary arms race of molecular interactions ????Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25704559 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25704559 #FOAvip English Wikipedia <ref>{{Cite pmid|25704559}}</ref> Interferons and viruses: an evolutionary arms race of molecular interactions #MMPMID25704559 Hoffmann HH; Schneider WM; Rice CM Trends Immunol 2015[Mar]; 36 (3): 124-38 PMID25704559show ga Over half a century has passed since interferons (IFNs) were discovered and shown to inhibit virus infection in cultured cells. Since then, researchers have steadily brought to light the molecular details of IFN signaling, catalogued their pleiotropic effects on cells, and harnessed their therapeutic potential for a variety of maladies. While advances have been plentiful, several fundamental questions have yet to be answered and much complexity remains to be unraveled. We explore the current knowledge surrounding four main questions: are type I IFN subtypes differentially produced in response to distinct pathogens? How are IFN subtypes distinguished by cells? What are the mechanisms and consequences of viral antagonism? Lastly, how can the IFN response be harnessed to improve vaccine efficacy? äInterferons and viruses: an evolutionary arms race of molecular intera(epmc).pdf DeepDyve Pubget Overpricing