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10.1038/nrm3741 http://scihub22266oqcxt.onion/10.1038/nrm3741 C4384331!4384331!24452470     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Mol+Cell+Biol 2014 ; 15 (2): 122-33 Nephropedia Template TP {{tp|p=24452470|t=2014. Regulated protein turnover: snapshots of the proteasome in action |pdf=|usr=}}{{24452470}} gab.com Text Regulated protein turnover: snapshots of the proteasome in action JO: Nat Rev Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=24452470 #FOAvip The ubiquitin-proteasome system (UPS) is the main ATP-dependent protein degradation pathway in the cytosol and nucleus of eukaryotic cells. At its centre is the 26S proteasome, which degrades regulatory proteins and mis-folded or damaged proteins. In a major breakthrough, several groups have determined high-resolution structures of the entire 26S proteasome particle in different nucleotide conditions and with and without substrate using cryo-electron microscopy combined with other techniques. These structures bring some surprising insights into the functional mechanism of the proteasome and will provide invaluable guidance for genetic and biochemical studies of this key regulatory system. Twit Text FOAVip Regulated protein turnover: snapshots of the proteasome in action ????Nat Rev Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=24452470 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24452470 #FOAvip English Wikipedia <ref>{{Cite pmid|24452470}}</ref> Regulated protein turnover: snapshots of the proteasome in action #MMPMID24452470 Bhattacharyya S; Yu H; Mim C; Matouschek A Nat Rev Mol Cell Biol 2014[Feb]; 15 (2): 122-33 PMID24452470show ga The ubiquitin-proteasome system (UPS) is the main ATP-dependent protein degradation pathway in the cytosol and nucleus of eukaryotic cells. At its centre is the 26S proteasome, which degrades regulatory proteins and mis-folded or damaged proteins. In a major breakthrough, several groups have determined high-resolution structures of the entire 26S proteasome particle in different nucleotide conditions and with and without substrate using cryo-electron microscopy combined with other techniques. These structures bring some surprising insights into the functional mechanism of the proteasome and will provide invaluable guidance for genetic and biochemical studies of this key regulatory system. äRegulated protein turnover: snapshots of the proteasome in action (epmc).pdf DeepDyve Pubget Overpricing