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10.1093/nar/gku770 http://scihub22266oqcxt.onion/10.1093/nar/gku770 C4384000!4384000 !25190456     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25190456 &cmd=llinks): Failed to open stream: HTTP request failed! 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The Candidate Cancer Gene Database: a database of cancer driver genes from forward genetic screens in mice |pdf=|usr=}}{{25190456 }} gab.com Text The Candidate Cancer Gene Database: a database of cancer driver genes from forward genetic screens in mice JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=25190456 #FOAvip Identification of cancer driver gene mutations is crucial for advancing cancer therapeutics. Due to the overwhelming number of passenger mutations in the human tumor genome, it is difficult to pinpoint causative driver genes. Using transposon mutagenesis in mice many laboratories have conducted forward genetic screens and identified thousands of candidate driver genes that are highly relevant to human cancer. Unfortunately, this information is difficult to access and utilize because it is scattered across multiple publications using different mouse genome builds and strength metrics. To improve access to these findings and facilitate meta-analyses, we developed the Candidate Cancer Gene Database (CCGD, http://ccgd-starrlab.oit.umn.edu/). The CCGD is a manually curated database containing a unified description of all identified candidate driver genes and the genomic location of transposon common insertion sites (CISs) from all currently published transposon-based screens. To demonstrate relevance to human cancer, we performed a modified gene set enrichment analysis using KEGG pathways and show that human cancer pathways are highly enriched in the database. We also used hierarchical clustering to identify pathways enriched in blood cancers compared to solid cancers. The CCGD is a novel resource available to scientists interested in the identification of genetic drivers of cancer. Twit Text FOAVip The Candidate Cancer Gene Database: a database of cancer driver genes from forward genetic screens in mice ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=25190456 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25190456 #FOAvip English Wikipedia <ref>{{Cite pmid|25190456 }}</ref> The Candidate Cancer Gene Database: a database of cancer driver genes from forward genetic screens in mice #MMPMID25190456 Abbott KL ; Nyre ET ; Abrahante J ; Ho YY ; Isaksson Vogel R ; Starr TK Nucleic Acids Res 2015[Jan]; 43 (Database issue ): D844-8 PMID25190456 show ga Identification of cancer driver gene mutations is crucial for advancing cancer therapeutics. Due to the overwhelming number of passenger mutations in the human tumor genome, it is difficult to pinpoint causative driver genes. Using transposon mutagenesis in mice many laboratories have conducted forward genetic screens and identified thousands of candidate driver genes that are highly relevant to human cancer. Unfortunately, this information is difficult to access and utilize because it is scattered across multiple publications using different mouse genome builds and strength metrics. To improve access to these findings and facilitate meta-analyses, we developed the Candidate Cancer Gene Database (CCGD, http://ccgd-starrlab.oit.umn.edu/). The CCGD is a manually curated database containing a unified description of all identified candidate driver genes and the genomic location of transposon common insertion sites (CISs) from all currently published transposon-based screens. To demonstrate relevance to human cancer, we performed a modified gene set enrichment analysis using KEGG pathways and show that human cancer pathways are highly enriched in the database. We also used hierarchical clustering to identify pathways enriched in blood cancers compared to solid cancers. The CCGD is a novel resource available to scientists interested in the identification of genetic drivers of cancer. |*Databases, Genetic [MESH] |*Genes, Neoplasm [MESH] |Animals [MESH] |Genetic Techniques [MESH] |Humans [MESH] |Internet [MESH] |Interspersed Repetitive Sequences [MESH]The Candidate Cancer Gene Database: a database of cancer driver genes (epmc).pdf DeepDyve Pubget Overpricing