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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Nucleic+Acids+Res
2015 ; 43
(Database issue
): D153-9
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English Wikipedia
DIANA-TarBase v7 0: indexing more than half a million experimentally supported
miRNA:mRNA interactions
#MMPMID25416803
Vlachos IS
; Paraskevopoulou MD
; Karagkouni D
; Georgakilas G
; Vergoulis T
; Kanellos I
; Anastasopoulos IL
; Maniou S
; Karathanou K
; Kalfakakou D
; Fevgas A
; Dalamagas T
; Hatzigeorgiou AG
Nucleic Acids Res
2015[Jan]; 43
(Database issue
): D153-9
PMID25416803
show ga
microRNAs (miRNAs) are short non-coding RNA species, which act as potent gene
expression regulators. Accurate identification of miRNA targets is crucial to
understanding their function. Currently, hundreds of thousands of miRNA:gene
interactions have been experimentally identified. However, this wealth of
information is fragmented and hidden in thousands of manuscripts and raw
next-generation sequencing data sets. DIANA-TarBase was initially released in
2006 and it was the first database aiming to catalog published experimentally
validated miRNA:gene interactions. DIANA-TarBase v7.0
(http://www.microrna.gr/tarbase) aims to provide for the first time hundreds of
thousands of high-quality manually curated experimentally validated miRNA:gene
interactions, enhanced with detailed meta-data. DIANA-TarBase v7.0 enables users
to easily identify positive or negative experimental results, the utilized
experimental methodology, experimental conditions including cell/tissue type and
treatment. The new interface provides also advanced information ranging from the
binding site location, as identified experimentally as well as in silico, to the
primer sequences used for cloning experiments. More than half a million
miRNA:gene interactions have been curated from published experiments on 356
different cell types from 24 species, corresponding to 9- to 250-fold more
entries than any other relevant database. DIANA-TarBase v7.0 is freely available.