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2015 ; 43
(Database issue
): D1171-5
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gab.com Text
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English Wikipedia
INFRAFRONTIER--providing mutant mouse resources as research tools for the
international scientific community
#MMPMID25414328
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Nucleic Acids Res
2015[Jan]; 43
(Database issue
): D1171-5
PMID25414328
show ga
The laboratory mouse is a key model organism to investigate mechanism and
therapeutics of human disease. The number of targeted genetic mouse models of
disease is growing rapidly due to high-throughput production strategies employed
by the International Mouse Phenotyping Consortium (IMPC) and the development of
new, more efficient genome engineering techniques such as CRISPR based systems.
We have previously described the European Mouse Mutant Archive (EMMA) resource
and how this international infrastructure provides archiving and distribution
worldwide for mutant mouse strains. EMMA has since evolved into INFRAFRONTIER
(http://www.infrafrontier.eu), the pan-European research infrastructure for the
systemic phenotyping, archiving and distribution of mouse disease models. Here we
describe new features including improved search for mouse strains, support for
new embryonic stem cell resources, access to training materials via a
comprehensive knowledgebase and the promotion of innovative analytical and
diagnostic techniques.