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10.1371/journal.pone.0122442 http://scihub22266oqcxt.onion/10.1371/journal.pone.0122442 C4383530!4383530 !25836370     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25836370 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2015 ; 10 (4 ): e0122442 Nephropedia Template TP {{tp|p=25836370 |t=2015. Glucocorticoids suppress renal cell carcinoma progression by enhancing Na,K-ATPase beta-1 subunit expression |pdf=|usr=}}{{25836370 }} gab.com Text Glucocorticoids suppress renal cell carcinoma progression by enhancing Na,K-ATPase beta-1 subunit expression JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=25836370 #FOAvip Glucocorticoids are commonly used as palliative or chemotherapeutic clinical agents for treatment of a variety of cancers. Although steroid treatment is beneficial, the mechanisms by which steroids improve outcome in cancer patients are not well understood. Na,K-ATPase beta-subunit isoform 1 (NaK-?1) is a cell-cell adhesion molecule, and its expression is down-regulated in cancer cells undergoing epithelial-to mesenchymal-transition (EMT), a key event associated with cancer progression to metastatic disease. In this study, we performed high-throughput screening to identify small molecules that could up-regulate NaK-?1 expression in cancer cells. Compounds related to the glucocorticoids were identified as drug candidates enhancing NaK-?1 expression. Of these compounds, triamcinolone, dexamethasone, and fluorometholone were validated to increase NaK-?1 expression at the cell surface, enhance cell-cell adhesion, attenuate motility and invasiveness and induce mesenchymal to epithelial like transition of renal cell carcinoma (RCC) cells in vitro. Treatment of NaK-?1 knockdown cells with these drug candidates confirmed that these compounds mediate their effects through up-regulating NaK-?1. Furthermore, we demonstrated that these compounds attenuate tumor growth in subcutaneous RCC xenografts and reduce local invasiveness in orthotopically-implanted tumors. Our results strongly indicate that the addition of glucocorticoids in the treatment of RCC may improve outcome for RCC patients by augmenting NaK-?1 cell-cell adhesion function. Twit Text FOAVip Glucocorticoids suppress renal cell carcinoma progression by enhancing Na,K-ATPase beta-1 subunit expression ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=25836370 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25836370 #FOAvip English Wikipedia <ref>{{Cite pmid|25836370 }}</ref> Glucocorticoids suppress renal cell carcinoma progression by enhancing Na,K-ATPase beta-1 subunit expression #MMPMID25836370 Huynh TP ; Barwe SP ; Lee SJ ; McSpadden R ; Franco OE ; Hayward SW ; Damoiseaux R ; Grubbs SS ; Petrelli NJ ; Rajasekaran AK PLoS One 2015[]; 10 (4 ): e0122442 PMID25836370 show ga Glucocorticoids are commonly used as palliative or chemotherapeutic clinical agents for treatment of a variety of cancers. Although steroid treatment is beneficial, the mechanisms by which steroids improve outcome in cancer patients are not well understood. Na,K-ATPase beta-subunit isoform 1 (NaK-?1) is a cell-cell adhesion molecule, and its expression is down-regulated in cancer cells undergoing epithelial-to mesenchymal-transition (EMT), a key event associated with cancer progression to metastatic disease. In this study, we performed high-throughput screening to identify small molecules that could up-regulate NaK-?1 expression in cancer cells. Compounds related to the glucocorticoids were identified as drug candidates enhancing NaK-?1 expression. Of these compounds, triamcinolone, dexamethasone, and fluorometholone were validated to increase NaK-?1 expression at the cell surface, enhance cell-cell adhesion, attenuate motility and invasiveness and induce mesenchymal to epithelial like transition of renal cell carcinoma (RCC) cells in vitro. Treatment of NaK-?1 knockdown cells with these drug candidates confirmed that these compounds mediate their effects through up-regulating NaK-?1. Furthermore, we demonstrated that these compounds attenuate tumor growth in subcutaneous RCC xenografts and reduce local invasiveness in orthotopically-implanted tumors. Our results strongly indicate that the addition of glucocorticoids in the treatment of RCC may improve outcome for RCC patients by augmenting NaK-?1 cell-cell adhesion function. |Animals [MESH] |Carcinoma, Renal Cell/*drug therapy/*enzymology/pathology [MESH] |Cell Adhesion/drug effects [MESH] |Cell Line, Tumor [MESH] |Dexamethasone/pharmacology [MESH] |Disease Progression [MESH] |Fluorometholone/pharmacology [MESH] |Glucocorticoids/*pharmacology [MESH] |HeLa Cells [MESH] |High-Throughput Screening Assays [MESH] |Humans [MESH] |Kidney Neoplasms/*drug therapy/*enzymology/pathology [MESH] |Male [MESH] |Mice [MESH] |Mice, Hairless [MESH] |Mice, SCID [MESH] |Neoplasm Invasiveness/prevention & control [MESH] |Promoter Regions, Genetic/drug effects [MESH] |RNA, Messenger/genetics/metabolism [MESH] |RNA, Neoplasm/genetics/metabolism [MESH] |Sodium-Potassium-Exchanging ATPase/genetics/*metabolism [MESH] |Triamcinolone/pharmacology [MESH] |Up-Regulation/drug effects [MESH]Glucocorticoids suppress renal cell carcinoma progression by enhancing(epmc).pdf DeepDyve Pubget Overpricing