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10.1155/2015/807976

http://scihub22266oqcxt.onion/10.1155/2015/807976
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C4383490!4383490!25873772
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suck abstract from ncbi

pmid25873772      Mediators+Inflamm 2015 ; 2015 (ä): ä
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  • Role of IL-38 and Its Related Cytokines in Inflammation #MMPMID25873772
  • Yuan X; Peng X; Li Y; Li M
  • Mediators Inflamm 2015[]; 2015 (ä): ä PMID25873772show ga
  • Interleukin- (IL-) 38 is a recently discovered cytokine and is the tenth member of the IL-1 cytokine family. IL-38 shares structural features with IL-1 receptor antagonist (IL-1Ra) and IL-36Ra. IL-36R is the specific receptor of IL-38, a partial receptor antagonist of IL-36. IL-38 inhibits the production of T-cell cytokines IL-17 and IL-22. IL-38 also inhibits the production of IL-8 induced by IL-36?, thus inhibiting inflammatory responses. IL-38-related cytokines, including IL-1Ra and IL-36Ra, are involved in the regulation of inflammation and immune responses. The study of IL-38 and IL-38-related cytokines might provide new insights for developing anti-inflammatory treatments in the near future.
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