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10.1155/2015/487256 http://scihub22266oqcxt.onion/10.1155/2015/487256 C4383472!4383472!25866786     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Res+Int 2015 ; 2015 (ä): ä Nephropedia Template TP {{tp|p=25866786|t=2015. Ouabain-Induced Cytoplasmic Vesicles and Their Role in Cell Volume Maintenance |pdf=|usr=}}{{25866786}} gab.com Text Ouabain-Induced Cytoplasmic Vesicles and Their Role in Cell Volume Maintenance JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=25866786 #FOAvip Cellular swelling is controlled by an active mechanism of cell volume regulation driven by a Na+/K+-dependent ATPase and by aquaporins which translocate water along the osmotic gradient. Na+/K+-pump may be blocked by ouabain, a digitalic derivative, by inhibition of ATP, or by drastic ion alterations of extracellular fluid. However, it has been observed that some tissues are still able to control their volume despite the presence of ouabain, suggesting the existence of other mechanisms of cell volume control. In 1977, by correlating electron microscopy observation with ion and water composition of liver slices incubated in different metabolic conditions in the presence or absence of ouabain, we observed that hepatocytes were able to control their volume extruding water and recovering ion composition in the presence of ouabain. In particular, hepatocytes were able to sequester ions and water in intracellular vesicles and then secrete them at the bile canaliculus pole. We named this ?vesicular mechanism of cell volume control.? Afterward, this mechanism has been confirmed by us and other laboratories in several mammalian tissues. This review summarizes evidences regarding this mechanism, problems that are still pending, and questions that need to be answered. Finally, we shortly review the importance of cell volume control in some human pathological conditions. Twit Text FOAVip Ouabain-Induced Cytoplasmic Vesicles and Their Role in Cell Volume Maintenance ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=25866786 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25866786 #FOAvip English Wikipedia <ref>{{Cite pmid|25866786}}</ref> Ouabain-Induced Cytoplasmic Vesicles and Their Role in Cell Volume Maintenance #MMPMID25866786 Russo MA; Morgante E; Russo A; van Rossum GD; Tafani M Biomed Res Int 2015[]; 2015 (ä): ä PMID25866786show ga Cellular swelling is controlled by an active mechanism of cell volume regulation driven by a Na+/K+-dependent ATPase and by aquaporins which translocate water along the osmotic gradient. Na+/K+-pump may be blocked by ouabain, a digitalic derivative, by inhibition of ATP, or by drastic ion alterations of extracellular fluid. However, it has been observed that some tissues are still able to control their volume despite the presence of ouabain, suggesting the existence of other mechanisms of cell volume control. In 1977, by correlating electron microscopy observation with ion and water composition of liver slices incubated in different metabolic conditions in the presence or absence of ouabain, we observed that hepatocytes were able to control their volume extruding water and recovering ion composition in the presence of ouabain. In particular, hepatocytes were able to sequester ions and water in intracellular vesicles and then secrete them at the bile canaliculus pole. We named this ?vesicular mechanism of cell volume control.? Afterward, this mechanism has been confirmed by us and other laboratories in several mammalian tissues. This review summarizes evidences regarding this mechanism, problems that are still pending, and questions that need to be answered. Finally, we shortly review the importance of cell volume control in some human pathological conditions. äOuabain-Induced Cytoplasmic Vesicles and Their Role in Cell Volume Mai(epmc).pdf DeepDyve Pubget Overpricing