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10.1186/s12916-015-0310-y http://scihub22266oqcxt.onion/10.1186/s12916-015-0310-y C4382850!4382850!25889215     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Med 2015 ; 13 (ä): ä Nephropedia Template TP {{tp|p=25889215|t=2015. The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders |pdf=|usr=}}{{25889215}} gab.com Text The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders JO: BMC Med http://www.kidney.de/pget.php?&tw=1&pmid=25889215 #FOAvip Background: Mitochondrial dysfunction and defects in oxidative metabolism are a characteristic feature of many chronic illnesses not currently classified as mitochondrial diseases. Examples of such illnesses include bipolar disorder, multiple sclerosis, Parkinson?s disease, schizophrenia, depression, autism, and chronic fatigue syndrome. Discussion: While the majority of patients with multiple sclerosis appear to have widespread mitochondrial dysfunction and impaired ATP production, the findings in patients diagnosed with Parkinson?s disease, autism, depression, bipolar disorder schizophrenia and chronic fatigue syndrome are less consistent, likely reflecting the fact that these diagnoses do not represent a disease with a unitary pathogenesis and pathophysiology. However, investigations have revealed the presence of chronic oxidative stress to be an almost invariant finding in study cohorts of patients afforded each diagnosis. This state is characterized by elevated reactive oxygen and nitrogen species and/or reduced levels of glutathione, and goes hand in hand with chronic systemic inflammation with elevated levels of pro-inflammatory cytokines. Summary: This paper details mechanisms by which elevated levels of reactive oxygen and nitrogen species together with elevated pro-inflammatory cytokines could conspire to pave a major road to the development of mitochondrial dysfunction and impaired oxidative metabolism seen in many patients diagnosed with these disorders. Twit Text FOAVip The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders ????BMC Med http://www.kidney.de/pget.php?&tw=1&pmid=25889215 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25889215 #FOAvip English Wikipedia <ref>{{Cite pmid|25889215}}</ref> The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders #MMPMID25889215 Morris G; Berk M BMC Med 2015[]; 13 (ä): ä PMID25889215show ga Background: Mitochondrial dysfunction and defects in oxidative metabolism are a characteristic feature of many chronic illnesses not currently classified as mitochondrial diseases. Examples of such illnesses include bipolar disorder, multiple sclerosis, Parkinson?s disease, schizophrenia, depression, autism, and chronic fatigue syndrome. Discussion: While the majority of patients with multiple sclerosis appear to have widespread mitochondrial dysfunction and impaired ATP production, the findings in patients diagnosed with Parkinson?s disease, autism, depression, bipolar disorder schizophrenia and chronic fatigue syndrome are less consistent, likely reflecting the fact that these diagnoses do not represent a disease with a unitary pathogenesis and pathophysiology. However, investigations have revealed the presence of chronic oxidative stress to be an almost invariant finding in study cohorts of patients afforded each diagnosis. This state is characterized by elevated reactive oxygen and nitrogen species and/or reduced levels of glutathione, and goes hand in hand with chronic systemic inflammation with elevated levels of pro-inflammatory cytokines. Summary: This paper details mechanisms by which elevated levels of reactive oxygen and nitrogen species together with elevated pro-inflammatory cytokines could conspire to pave a major road to the development of mitochondrial dysfunction and impaired oxidative metabolism seen in many patients diagnosed with these disorders. äThe many roads to mitochondrial dysfunction in neuroimmune and neurops(epmc).pdf DeepDyve Pubget Overpricing