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10.1186/s12967-015-0439-7 http://scihub22266oqcxt.onion/10.1186/s12967-015-0439-7 C4382841!4382841!25886458     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Transl+Med 2015 ; 13 (ä): ä Nephropedia Template TP {{tp|p=25886458|t=2015. Aquaporins as diagnostic and therapeutic targets in cancer: How far we are?|pdf=|usr=}}{{25886458}} gab.com Text Aquaporins as diagnostic and therapeutic targets in cancer: How far we are JO: J Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=25886458 #FOAvip Aquaporins (AQPs) are a family of water channel proteins distributed in various human tissues, responsible for the transport of small solutes such as glycerol, even gas and ions. The expression of AQPs has been found in more than 20 human cancer types and is significantly correlated with the severity of histological tumors and prognosis of patients with cancer. More recent evidence showed that AQPs could also play a role in tumor-associated edema, tumor cell proliferation and migration, and tumor angiogenesis in solid and hematological tumors. Inhibitors of AQPs in tumor cells and microvessels have been suggested as new therapeutic strategies. The present review overviews AQPs structures, expression variation among normal tissues and tumors, AQPs functions and roles in the development of cancer with special focuses on lung, colorectal, liver, brain and breast cancers, and potential AQPs-target inhibitors. We call the special attention to consider AQPs important as diagnostic and therapeutic biomarkers. It may be a novel anticancer therapy by the AQPs inhibition. Twit Text FOAVip Aquaporins as diagnostic and therapeutic targets in cancer: How far we are ????J Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=25886458 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25886458 #FOAvip English Wikipedia <ref>{{Cite pmid|25886458}}</ref> Aquaporins as diagnostic and therapeutic targets in cancer: How far we are? #MMPMID25886458 Wang J; Feng L; Zhu Z; Zheng M; Wang D; Chen Z; Sun H J Transl Med 2015[]; 13 (ä): ä PMID25886458show ga Aquaporins (AQPs) are a family of water channel proteins distributed in various human tissues, responsible for the transport of small solutes such as glycerol, even gas and ions. The expression of AQPs has been found in more than 20 human cancer types and is significantly correlated with the severity of histological tumors and prognosis of patients with cancer. More recent evidence showed that AQPs could also play a role in tumor-associated edema, tumor cell proliferation and migration, and tumor angiogenesis in solid and hematological tumors. Inhibitors of AQPs in tumor cells and microvessels have been suggested as new therapeutic strategies. The present review overviews AQPs structures, expression variation among normal tissues and tumors, AQPs functions and roles in the development of cancer with special focuses on lung, colorectal, liver, brain and breast cancers, and potential AQPs-target inhibitors. We call the special attention to consider AQPs important as diagnostic and therapeutic biomarkers. It may be a novel anticancer therapy by the AQPs inhibition. äAquaporins as diagnostic and therapeutic targets in cancer: How far we(epmc).pdf DeepDyve Pubget Overpricing