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10.1101/cshperspect.a021501 http://scihub22266oqcxt.onion/10.1101/cshperspect.a021501 C4382723!4382723!25833942     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cold+Spring+Harb+Perspect+Med 2015 ; 5 (4): ä Nephropedia Template TP {{tp|p=25833942|t=2015. Antiviral Therapies and Prospects for a Cure of Chronic Hepatitis B |pdf=|usr=}}{{25833942}} gab.com Text Antiviral Therapies and Prospects for a Cure of Chronic Hepatitis B JO: Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=25833942 #FOAvip Current therapies of chronic hepatitis B (CHB) remain limited to either pegylated interferon-? (Peg-IFN-?), or one of the five approved nucleoside analog (NA) treatments. Although viral suppression can be achieved in the majority of patients with high-barrier-to-resistance new-generation NAs (i.e., entecavir and tenofovir), HBsAg loss is achieved in only 10% of patients with both classes of drugs after a follow-up of 5 years. Attempts to improve the response by administering two different NAs or a combination of NA and Peg-IFN-? have been unsuccessful. Therefore, there is a renewed interest to investigate a number of steps in the hepatitis B virus (HBV) replication cycle and specific virus?host cell interactions as potential targets for new antivirals. Novel targets and compounds could readily be evaluated using both relevant in vitro and newly developed in vivo models of HBV infection. The addition of one or several new drugs to current regimens should offer the prospect of markedly improving the response to therapy, thus reducing the burden of drug resistance, as well as the incidence of cirrhosis and hepatocellular carcinoma (HCC). Twit Text FOAVip Antiviral Therapies and Prospects for a Cure of Chronic Hepatitis B ????Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=25833942 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25833942 #FOAvip English Wikipedia <ref>{{Cite pmid|25833942}}</ref> Antiviral Therapies and Prospects for a Cure of Chronic Hepatitis B #MMPMID25833942 Zoulim F; Durantel D Cold Spring Harb Perspect Med 2015[Apr]; 5 (4): ä PMID25833942show ga Current therapies of chronic hepatitis B (CHB) remain limited to either pegylated interferon-? (Peg-IFN-?), or one of the five approved nucleoside analog (NA) treatments. Although viral suppression can be achieved in the majority of patients with high-barrier-to-resistance new-generation NAs (i.e., entecavir and tenofovir), HBsAg loss is achieved in only 10% of patients with both classes of drugs after a follow-up of 5 years. Attempts to improve the response by administering two different NAs or a combination of NA and Peg-IFN-? have been unsuccessful. Therefore, there is a renewed interest to investigate a number of steps in the hepatitis B virus (HBV) replication cycle and specific virus?host cell interactions as potential targets for new antivirals. Novel targets and compounds could readily be evaluated using both relevant in vitro and newly developed in vivo models of HBV infection. The addition of one or several new drugs to current regimens should offer the prospect of markedly improving the response to therapy, thus reducing the burden of drug resistance, as well as the incidence of cirrhosis and hepatocellular carcinoma (HCC). äAntiviral Therapies and Prospects for a Cure of Chronic Hepatitis B (epmc).pdf DeepDyve Pubget Overpricing