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10.1038/bcj.2015.10 http://scihub22266oqcxt.onion/10.1038/bcj.2015.10 C4382653!4382653 !25768400     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25768400 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Blood+Cancer+J 2015 ; 5 (3 ): 287 Nephropedia Template TP {{tp|p=25768400 |t=2015. Dysregulated choline metabolism in T-cell lymphoma: role of choline kinase-? and therapeutic targeting |pdf=|usr=}}{{25768400 }} gab.com Text Dysregulated choline metabolism in T-cell lymphoma: role of choline kinase- and therapeutic targeting JO: Blood Cancer J http://www.kidney.de/pget.php?&tw=1&pmid=25768400 #FOAvip Cancer cells have distinct metabolomic profile. Metabolic enzymes regulate key oncogenic signaling pathways and have an essential role on tumor progression. Here, serum metabolomic analysis was performed in 45 patients with T-cell lymphoma (TCL) and 50 healthy volunteers. The results showed that dysregulation of choline metabolism occurred in TCL and was related to tumor cell overexpression of choline kinase-? (Chok?). In T-lymphoma cells, pharmacological and molecular silencing of Chok? significantly decreased Ras-GTP activity, AKT and ERK phosphorylation and MYC oncoprotein expression, leading to restoration of choline metabolites and induction of tumor cell apoptosis/necropotosis. In a T-lymphoma xenograft murine model, Chok? inhibitor CK37 remarkably retarded tumor growth, suppressed Ras-AKT/ERK signaling, increased lysophosphatidylcholine levels and induced in situ cell apoptosis/necropotosis. Collectively, as a regulatory gene of aberrant choline metabolism, Chok? possessed oncogenic activity and could be a potential therapeutic target in TCL, as well as other hematological malignancies with interrupted Ras signaling pathways. Twit Text FOAVip Dysregulated choline metabolism in T-cell lymphoma: role of choline kinase- and therapeutic targeting ????Blood Cancer J http://www.kidney.de/pget.php?&tw=1&pmid=25768400 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25768400 #FOAvip English Wikipedia <ref>{{Cite pmid|25768400 }}</ref> Dysregulated choline metabolism in T-cell lymphoma: role of choline kinase-? and therapeutic targeting #MMPMID25768400 Xiong J ; Bian J ; Wang L ; Zhou JY ; Wang Y ; Zhao Y ; Wu LL ; Hu JJ ; Li B ; Chen SJ ; Yan C ; Zhao WL Blood Cancer J 2015[Mar]; 5 (3 ): 287 PMID25768400 show ga Cancer cells have distinct metabolomic profile. Metabolic enzymes regulate key oncogenic signaling pathways and have an essential role on tumor progression. Here, serum metabolomic analysis was performed in 45 patients with T-cell lymphoma (TCL) and 50 healthy volunteers. The results showed that dysregulation of choline metabolism occurred in TCL and was related to tumor cell overexpression of choline kinase-? (Chok?). In T-lymphoma cells, pharmacological and molecular silencing of Chok? significantly decreased Ras-GTP activity, AKT and ERK phosphorylation and MYC oncoprotein expression, leading to restoration of choline metabolites and induction of tumor cell apoptosis/necropotosis. In a T-lymphoma xenograft murine model, Chok? inhibitor CK37 remarkably retarded tumor growth, suppressed Ras-AKT/ERK signaling, increased lysophosphatidylcholine levels and induced in situ cell apoptosis/necropotosis. Collectively, as a regulatory gene of aberrant choline metabolism, Chok? possessed oncogenic activity and could be a potential therapeutic target in TCL, as well as other hematological malignancies with interrupted Ras signaling pathways. |Adult [MESH] |Aged [MESH] |Animals [MESH] |Apoptosis/genetics [MESH] |Choline Kinase/antagonists & inhibitors/*biosynthesis/blood [MESH] |Choline/*blood [MESH] |Enzyme Inhibitors/administration & dosage [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic/drug effects [MESH] |Humans [MESH] |Lymphoma, T-Cell/*blood/genetics/pathology [MESH] |Male [MESH] |Mice [MESH] |Middle Aged [MESH] |Molecular Targeted Therapy [MESH]Dysregulated choline metabolism in T-cell lymphoma: role of choline ki(epmc).pdf DeepDyve Pubget Overpricing