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10.1159/000368411 http://scihub22266oqcxt.onion/10.1159/000368411 C4382204!4382204!25412793     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nephron+Exp+Nephrol 2014 ; 128 (ä): 80-8 Nephropedia Template TP {{tp|p=25412793|t=2014. Wnt5a Is Necessary for Normal Kidney Development in Zebrafish and Mice |pdf=|usr=}}{{25412793}} gab.com Text Wnt5a Is Necessary for Normal Kidney Development in Zebrafish and Mice JO: Nephron Exp Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25412793 #FOAvip Background: Wnt5a is important for the development of various organs and postnatal cellular function. Little is known, however, about the role of Wnt5a in kidney development, although WNT5A mutations were identified in patients with Robinow syndrome, a genetic disease which includes developmental defects in kidneys. Our goal in this study was to determine the role of Wnt5a in kidney development. Methods: Whole-mount in situ hybridization was used to establish the expression pattern of Wnt5a during kidney development. Zebrafish with wnt5a knockdown and Wnt5a global knockout mice were used to identify kidney phenotypes. Results: In zebrafish, wnt5a knockdown resulted in glomerular cyst formation and dilated renal tubules. In mice, Wnt5a global knockout resulted in pleiotropic, but severe, kidney phenotypes, including agenesis, fused kidney, hydronephrosis and duplex kidney/ureter. Conclusions: Our data demonstrated the important role of Wnt5a in kidney development. Disrupted Wnt5a resulted in kidney cysts in zebrafish and pleiotropic abnormal kidney development in mice. Twit Text FOAVip Wnt5a Is Necessary for Normal Kidney Development in Zebrafish and Mice ????Nephron Exp Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25412793 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25412793 #FOAvip English Wikipedia <ref>{{Cite pmid|25412793}}</ref> Wnt5a Is Necessary for Normal Kidney Development in Zebrafish and Mice #MMPMID25412793 Huang L; Xiao A; Choi SY; Kan Q; Zhou W; Chacon-Heszele MF; Ryu YK; McKenna S; Zuo X; Kuruvilla R; Lipschutz JH Nephron Exp Nephrol 2014[]; 128 (ä): 80-8 PMID25412793show ga Background: Wnt5a is important for the development of various organs and postnatal cellular function. Little is known, however, about the role of Wnt5a in kidney development, although WNT5A mutations were identified in patients with Robinow syndrome, a genetic disease which includes developmental defects in kidneys. Our goal in this study was to determine the role of Wnt5a in kidney development. Methods: Whole-mount in situ hybridization was used to establish the expression pattern of Wnt5a during kidney development. Zebrafish with wnt5a knockdown and Wnt5a global knockout mice were used to identify kidney phenotypes. Results: In zebrafish, wnt5a knockdown resulted in glomerular cyst formation and dilated renal tubules. In mice, Wnt5a global knockout resulted in pleiotropic, but severe, kidney phenotypes, including agenesis, fused kidney, hydronephrosis and duplex kidney/ureter. Conclusions: Our data demonstrated the important role of Wnt5a in kidney development. Disrupted Wnt5a resulted in kidney cysts in zebrafish and pleiotropic abnormal kidney development in mice. äWnt5a Is Necessary for Normal Kidney Development in Zebrafish and Mice(epmc).pdf DeepDyve Pubget Overpricing