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10.1080/19466315.2014.1003090

http://scihub22266oqcxt.onion/10.1080/19466315.2014.1003090
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C4382106!4382106!25844122
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suck abstract from ncbi


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pmid25844122      Stat+Biopharm+Res 2015 ; 7 (1): 36-54
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  • Group-Sequential Strategies in Clinical Trials with Multiple Co-Primary Outcomes #MMPMID25844122
  • Hamasaki T; Asakura K; Evans SR; Sugimoto T; Sozu T
  • Stat Biopharm Res 2015[]; 7 (1): 36-54 PMID25844122show ga
  • We discuss the decision-making frameworks for clinical trials with multiple co-primary endpoints in a group-sequential setting. The decision-making frameworks can account for flexibilities such as a varying number of analyses, equally or unequally spaced increments of information and fixed or adaptive Type I error allocation among endpoints. The frameworks can provide efficiency, i.e., potentially fewer trial participants, than the fixed sample size designs. We investigate the operating characteristics of the decision-making frameworks and provide guidance on constructing efficient group-sequential strategies in clinical trials with multiple co-primary endpoints.
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