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10.2147/DDDT.S77341 http://scihub22266oqcxt.onion/10.2147/DDDT.S77341 C4381899!4381899 !25848216     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25848216 &cmd=llinks): Failed to open stream: HTTP request failed! 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Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells |pdf=|usr=}}{{25848216 }} gab.com Text Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells JO: Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=25848216 #FOAvip It is becoming increasingly understood that tumor cells may have different mutations and dependencies on diverse intracellular signaling cascades for survival or metastatic potential. Overexpression of oncogenes, inactivation of tumor suppressor genes, genetic/epigenetic mutations, genomic instability, and loss of apoptotic cell death are some of the mechanisms that have been widely investigated in molecular oncology. We partition this multicomponent review into the most recent evidence on the anticancer activity of fungal substances obtained from in vitro and xenografted models, and these fungal substances modulate expression of oncogenic and tumor suppressor miRNAs. There are some outstanding questions regarding fungus-derived chemical-induced modulation of intracellular signaling networks in different cancer cell lines and preclinical models. Certain hints have emerged, emphasizing mechanisms via which apoptosis can be restored in TRAIL-resistant cancer cells. Reconceptualization of the knowledge obtained from these emerging areas of research will enable us to potentially identify natural agents with notable anticancer activity and minimal off-target effects. Integration of experimentally verified evidence obtained from cancer cell line gene expression with large-scale functional screening results and pharmacological sensitivity data will be helpful in identification of therapeutics with substantial efficacy. New tools and technologies will further deepen our understanding of the signaling networks that underlie the development of cancer, metastasis, and resistance to different therapeutics at both a personal and systems-wide level. Twit Text FOAVip Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells ????Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=25848216 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25848216 #FOAvip English Wikipedia <ref>{{Cite pmid|25848216 }}</ref> Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells #MMPMID25848216 Lin X ; Farooqi AA ; Ismail M Drug Des Devel Ther 2015[]; 9 (ä): 1797-804 PMID25848216 show ga It is becoming increasingly understood that tumor cells may have different mutations and dependencies on diverse intracellular signaling cascades for survival or metastatic potential. Overexpression of oncogenes, inactivation of tumor suppressor genes, genetic/epigenetic mutations, genomic instability, and loss of apoptotic cell death are some of the mechanisms that have been widely investigated in molecular oncology. We partition this multicomponent review into the most recent evidence on the anticancer activity of fungal substances obtained from in vitro and xenografted models, and these fungal substances modulate expression of oncogenic and tumor suppressor miRNAs. There are some outstanding questions regarding fungus-derived chemical-induced modulation of intracellular signaling networks in different cancer cell lines and preclinical models. Certain hints have emerged, emphasizing mechanisms via which apoptosis can be restored in TRAIL-resistant cancer cells. Reconceptualization of the knowledge obtained from these emerging areas of research will enable us to potentially identify natural agents with notable anticancer activity and minimal off-target effects. Integration of experimentally verified evidence obtained from cancer cell line gene expression with large-scale functional screening results and pharmacological sensitivity data will be helpful in identification of therapeutics with substantial efficacy. New tools and technologies will further deepen our understanding of the signaling networks that underlie the development of cancer, metastasis, and resistance to different therapeutics at both a personal and systems-wide level. |Animals [MESH] |Antineoplastic Agents/chemistry/isolation & purification/*pharmacology [MESH] |Fungi/*chemistry [MESH] |Humans [MESH] |Neoplasms/*drug therapy/metabolism/pathology [MESH]Recent progress in fungus-derived bioactive agents for targeting of si(epmc).pdf DeepDyve Pubget Overpricing