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http://scihub22266oqcxt.onion/ C4381575!4381575!25622103     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2015 ; 6 (1): 7-25 Nephropedia Template TP {{tp|p=25622103|t=2015. MicroRNAs in B-cells: from normal differentiation to treatment of malignancies |pdf=|usr=}}{{25622103}} gab.com Text MicroRNAs in B-cells: from normal differentiation to treatment of malignancies JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25622103 #FOAvip MicroRNAs (miRNAs) are small non-coding RNAs that play important post-transcriptional regulatory roles in a wide range of biological processes. They are fundamental to the normal development of cells, and evidence suggests that the deregulation of specific miRNAs is involved in malignant transformation due to their function as oncogenes or tumor suppressors. We know that miRNAs are involved in the development of normal B-cells and that different B-cell subsets express specific miRNA profiles according to their degree of differentiation. B-cell-derived malignancies contain transcription signatures reminiscent of their cell of origin. Therefore, we believe that normal and malignant B-cells share features of regulatory networks controlling differentiation and the ability to respond to treatment. The involvement of miRNAs in these processes makes them good biomarker candidates. B-cell malignancies are highly prevalent, and the poor overall survival of patients with these malignancies demands an improvement in stratification according to prognosis and therapy response, wherein we believe miRNAs may be of great importance. We have critically reviewed the literature, and here we sum up the findings of miRNA studies in hematological cancers, from the development and progression of the disease to the response to treatment, with a particular emphasis on B-cell malignancies. Twit Text FOAVip MicroRNAs in B-cells: from normal differentiation to treatment of malignancies ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25622103 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25622103 #FOAvip English Wikipedia <ref>{{Cite pmid|25622103}}</ref> MicroRNAs in B-cells: from normal differentiation to treatment of malignancies #MMPMID25622103 Marques SC; Laursen MB; Bødker JS; Kjeldsen MK; Falgreen S; Schmitz A; Bøgsted M; Johnsen HE; Dybkaer K Oncotarget 2015[Jan]; 6 (1): 7-25 PMID25622103show ga MicroRNAs (miRNAs) are small non-coding RNAs that play important post-transcriptional regulatory roles in a wide range of biological processes. They are fundamental to the normal development of cells, and evidence suggests that the deregulation of specific miRNAs is involved in malignant transformation due to their function as oncogenes or tumor suppressors. We know that miRNAs are involved in the development of normal B-cells and that different B-cell subsets express specific miRNA profiles according to their degree of differentiation. B-cell-derived malignancies contain transcription signatures reminiscent of their cell of origin. Therefore, we believe that normal and malignant B-cells share features of regulatory networks controlling differentiation and the ability to respond to treatment. The involvement of miRNAs in these processes makes them good biomarker candidates. B-cell malignancies are highly prevalent, and the poor overall survival of patients with these malignancies demands an improvement in stratification according to prognosis and therapy response, wherein we believe miRNAs may be of great importance. We have critically reviewed the literature, and here we sum up the findings of miRNA studies in hematological cancers, from the development and progression of the disease to the response to treatment, with a particular emphasis on B-cell malignancies. äMicroRNAs in B-cells: from normal differentiation to treatment of mali(epmc).pdf DeepDyve Pubget Overpricing