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10.1146/annurev-pharmtox-011613-135915 http://scihub22266oqcxt.onion/10.1146/annurev-pharmtox-011613-135915 C4381542!4381542!24050701     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Annu+Rev+Pharmacol+Toxicol 2014 ; 54 (ä): 71-94 Nephropedia Template TP {{tp|p=24050701|t=2014. Antiparasitic chemotherapy ? from genomes to mechanisms |pdf=|usr=}}{{24050701}} gab.com Text Antiparasitic chemotherapy from genomes to mechanisms JO: Annu Rev Pharmacol Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=24050701 #FOAvip Due to the absence of antiparistic vaccines, and the constant threat of drug resistance, the development of novel antiparasitic chemotherapies remains of major importance for disease control. A better understanding of drug transport (uptake and efflux), metabolism and the identification of drug targets, as well as potential drug resistance mechanisms would facilitate the development of more effective therapies. Here, we focus on malaria and African tyrpanosaomiasis. We review existing drugs and drug development, emphasizing high-throughput genomic and genetic approaches, which hold great promise for elucidating anti-parasitic mechanisms. We describe the approaches and technologies that have been influential for each parasite and develop some new ideas for future research directions, including strategies for target deconvolution. Twit Text FOAVip Antiparasitic chemotherapy from genomes to mechanisms ????Annu Rev Pharmacol Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=24050701 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24050701 #FOAvip English Wikipedia <ref>{{Cite pmid|24050701}}</ref> Antiparasitic chemotherapy ? from genomes to mechanisms #MMPMID24050701 Horn D; Duraisingh MT Annu Rev Pharmacol Toxicol 2014[]; 54 (ä): 71-94 PMID24050701show ga Due to the absence of antiparistic vaccines, and the constant threat of drug resistance, the development of novel antiparasitic chemotherapies remains of major importance for disease control. A better understanding of drug transport (uptake and efflux), metabolism and the identification of drug targets, as well as potential drug resistance mechanisms would facilitate the development of more effective therapies. Here, we focus on malaria and African tyrpanosaomiasis. We review existing drugs and drug development, emphasizing high-throughput genomic and genetic approaches, which hold great promise for elucidating anti-parasitic mechanisms. We describe the approaches and technologies that have been influential for each parasite and develop some new ideas for future research directions, including strategies for target deconvolution. äAntiparasitic chemotherapy ? from genomes to mechanisms (epmc).pdf DeepDyve Pubget Overpricing