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10.1101/gr.185272.114 http://scihub22266oqcxt.onion/10.1101/gr.185272.114 C4381529!4381529!25752748     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genome+Res 2015 ; 25 (4): 582-97 Nephropedia Template TP {{tp|p=25752748|t=2015. The pluripotent regulatory circuitry connecting promoters to their long-range interacting elements |pdf=|usr=}}{{25752748}} gab.com Text The pluripotent regulatory circuitry connecting promoters to their long-range interacting elements JO: Genome Res http://www.kidney.de/pget.php?&tw=1&pmid=25752748 #FOAvip The mammalian genome harbors up to one million regulatory elements often located at great distances from their target genes. Long-range elements control genes through physical contact with promoters and can be recognized by the presence of specific histone modifications and transcription factor binding. Linking regulatory elements to specific promoters genome-wide is currently impeded by the limited resolution of high-throughput chromatin interaction assays. Here we apply a sequence capture approach to enrich Hi-C libraries for >22,000 annotated mouse promoters to identify statistically significant, long-range interactions at restriction fragment resolution, assigning long-range interacting elements to their target genes genome-wide in embryonic stem cells and fetal liver cells. The distal sites contacting active genes are enriched in active histone modifications and transcription factor occupancy, whereas inactive genes contact distal sites with repressive histone marks, demonstrating the regulatory potential of the distal elements identified. Furthermore, we find that coregulated genes cluster nonrandomly in spatial interaction networks correlated with their biological function and expression level. Interestingly, we find the strongest gene clustering in ES cells between transcription factor genes that control key developmental processes in embryogenesis. The results provide the first genome-wide catalog linking gene promoters to their long-range interacting elements and highlight the complex spatial regulatory circuitry controlling mammalian gene expression. Twit Text FOAVip The pluripotent regulatory circuitry connecting promoters to their long-range interacting elements ????Genome Res http://www.kidney.de/pget.php?&tw=1&pmid=25752748 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25752748 #FOAvip English Wikipedia <ref>{{Cite pmid|25752748}}</ref> The pluripotent regulatory circuitry connecting promoters to their long-range interacting elements #MMPMID25752748 Schoenfelder S; Furlan-Magaril M; Mifsud B; Tavares-Cadete F; Sugar R; Javierre BM; Nagano T; Katsman Y; Sakthidevi M; Wingett SW; Dimitrova E; Dimond A; Edelman LB; Elderkin S; Tabbada K; Darbo E; Andrews S; Herman B; Higgs A; LeProust E; Osborne CS; Mitchell JA; Luscombe NM; Fraser P Genome Res 2015[Apr]; 25 (4): 582-97 PMID25752748show ga The mammalian genome harbors up to one million regulatory elements often located at great distances from their target genes. Long-range elements control genes through physical contact with promoters and can be recognized by the presence of specific histone modifications and transcription factor binding. Linking regulatory elements to specific promoters genome-wide is currently impeded by the limited resolution of high-throughput chromatin interaction assays. Here we apply a sequence capture approach to enrich Hi-C libraries for >22,000 annotated mouse promoters to identify statistically significant, long-range interactions at restriction fragment resolution, assigning long-range interacting elements to their target genes genome-wide in embryonic stem cells and fetal liver cells. The distal sites contacting active genes are enriched in active histone modifications and transcription factor occupancy, whereas inactive genes contact distal sites with repressive histone marks, demonstrating the regulatory potential of the distal elements identified. Furthermore, we find that coregulated genes cluster nonrandomly in spatial interaction networks correlated with their biological function and expression level. Interestingly, we find the strongest gene clustering in ES cells between transcription factor genes that control key developmental processes in embryogenesis. The results provide the first genome-wide catalog linking gene promoters to their long-range interacting elements and highlight the complex spatial regulatory circuitry controlling mammalian gene expression. äThe pluripotent regulatory circuitry connecting promoters to their lon(epmc).pdf DeepDyve Pubget Overpricing