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10.1101/gr.176099.114 http://scihub22266oqcxt.onion/10.1101/gr.176099.114 C4381527!4381527 !25762552     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25762552 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genome+Res 2015 ; 25 (4 ): 558-69 Nephropedia Template TP {{tp|p=25762552 |t=2015. Effect of minichromosome maintenance protein 2 deficiency on the locations of DNA replication origins |pdf=|usr=}}{{25762552 }} gab.com Text Effect of minichromosome maintenance protein 2 deficiency on the locations of DNA replication origins JO: Genome Res http://www.kidney.de/pget.php?&tw=1&pmid=25762552 #FOAvip Minichromosome maintenance (MCM) proteins are loaded onto chromatin during G1-phase and define potential locations of DNA replication initiation. MCM protein deficiency results in genome instability and high rates of cancer in mouse models. Here we develop a method of nascent strand capture and release and show that MCM2 deficiency reduces DNA replication initiation in gene-rich regions of the genome. DNA structural properties are shown to correlate with sequence motifs associated with replication origins and with locations that are preferentially affected by MCM2 deficiency. Reduced nascent strand density correlates with sites of recurrent focal CNVs in tumors arising in MCM2-deficient mice, consistent with a direct relationship between sites of reduced DNA replication initiation and genetic damage. Between 10% and 90% of human tumors, depending on type, carry heterozygous loss or mutation of one or more MCM2-7 genes, which is expected to compromise DNA replication origin licensing and result in elevated rates of genome damage at a subset of gene-rich locations. Twit Text FOAVip Effect of minichromosome maintenance protein 2 deficiency on the locations of DNA replication origins ????Genome Res http://www.kidney.de/pget.php?&tw=1&pmid=25762552 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25762552 #FOAvip English Wikipedia <ref>{{Cite pmid|25762552 }}</ref> Effect of minichromosome maintenance protein 2 deficiency on the locations of DNA replication origins #MMPMID25762552 Kunnev D ; Freeland A ; Qin M ; Leach RW ; Wang J ; Shenoy RM ; Pruitt SC Genome Res 2015[Apr]; 25 (4 ): 558-69 PMID25762552 show ga Minichromosome maintenance (MCM) proteins are loaded onto chromatin during G1-phase and define potential locations of DNA replication initiation. MCM protein deficiency results in genome instability and high rates of cancer in mouse models. Here we develop a method of nascent strand capture and release and show that MCM2 deficiency reduces DNA replication initiation in gene-rich regions of the genome. DNA structural properties are shown to correlate with sequence motifs associated with replication origins and with locations that are preferentially affected by MCM2 deficiency. Reduced nascent strand density correlates with sites of recurrent focal CNVs in tumors arising in MCM2-deficient mice, consistent with a direct relationship between sites of reduced DNA replication initiation and genetic damage. Between 10% and 90% of human tumors, depending on type, carry heterozygous loss or mutation of one or more MCM2-7 genes, which is expected to compromise DNA replication origin licensing and result in elevated rates of genome damage at a subset of gene-rich locations. |Animals [MESH] |Base Sequence [MESH] |Cell Line [MESH] |Chromatin/genetics [MESH] |DNA Copy Number Variations/genetics [MESH] |DNA Replication/*genetics [MESH] |G1 Phase/genetics [MESH] |Genomic Instability/genetics [MESH] |Humans [MESH] |Mice [MESH] |Minichromosome Maintenance Complex Component 2/*genetics [MESH] |Models, Animal [MESH] |Neoplasms/*genetics [MESH] |Replication Origin/*genetics [MESH]Effect of minichromosome maintenance protein 2 deficiency on the locat(epmc).pdf DeepDyve Pubget Overpricing