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10.1111/bjh.12725 http://scihub22266oqcxt.onion/10.1111/bjh.12725 C4381431!4381431!24405087     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Haematol 2014 ; 164 (6): 767-78 Nephropedia Template TP {{tp|p=24405087|t=2014. ADVANCES IN UNDERSTANDING THE LEUKEMIA MICROENVIRONMENT |pdf=|usr=}}{{24405087}} gab.com Text ADVANCES IN UNDERSTANDING THE LEUKEMIA MICROENVIRONMENT JO: Br J Haematol http://www.kidney.de/pget.php?&tw=1&pmid=24405087 #FOAvip Dynamic interactions between leukemic cells and cells of the bone marrow are a feature of hematological malignancies. Two distinct microenvironmental niches in the bone marrow, the ?osteoblastic (endosteal)? and ?vascular? niches, provide a sanctuary for subpopulations of leukemic cells to evade chemotherapy-induced death and allow acquisition of a drug-resistance. Key components of the bone marrow microenvironment as a home for normal hematopoietic stem cells and the leukemia stem cell niches, and the molecular pathways critical for microenvironment/leukemia interactions via cytokines, chemokines, and adhesion molecules as well as hypoxic conditions, are described in this review. Finally, the genetic abnormalities of leukemia-associated stroma are discussed. Further understanding of the contribution of the bone marrow niche to the process of leukemogenesis may provide new targets that allow destruction of leukemia stem cells without adversely affecting normal stem cell self-renewal. Twit Text FOAVip ADVANCES IN UNDERSTANDING THE LEUKEMIA MICROENVIRONMENT ????Br J Haematol http://www.kidney.de/pget.php?&tw=1&pmid=24405087 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24405087 #FOAvip English Wikipedia <ref>{{Cite pmid|24405087}}</ref> ADVANCES IN UNDERSTANDING THE LEUKEMIA MICROENVIRONMENT #MMPMID24405087 Tabe Y; Konopleva M Br J Haematol 2014[Mar]; 164 (6): 767-78 PMID24405087show ga Dynamic interactions between leukemic cells and cells of the bone marrow are a feature of hematological malignancies. Two distinct microenvironmental niches in the bone marrow, the ?osteoblastic (endosteal)? and ?vascular? niches, provide a sanctuary for subpopulations of leukemic cells to evade chemotherapy-induced death and allow acquisition of a drug-resistance. Key components of the bone marrow microenvironment as a home for normal hematopoietic stem cells and the leukemia stem cell niches, and the molecular pathways critical for microenvironment/leukemia interactions via cytokines, chemokines, and adhesion molecules as well as hypoxic conditions, are described in this review. Finally, the genetic abnormalities of leukemia-associated stroma are discussed. Further understanding of the contribution of the bone marrow niche to the process of leukemogenesis may provide new targets that allow destruction of leukemia stem cells without adversely affecting normal stem cell self-renewal. äADVANCES IN UNDERSTANDING THE LEUKEMIA MICROENVIRONMENT (epmc).pdf DeepDyve Pubget Overpricing