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Nd(III)-induced rice mitochondrial dysfunction investigated by spectroscopic and
microscopic methods
#MMPMID25650179
Xia CF
; Lv L
; Chen XY
; Fu BQ
; Lei KL
; Qin CQ
; Liu Y
J Membr Biol
2015[Apr]; 248
(2
): 319-26
PMID25650179
show ga
The production capacity and yield of neodymium (Nd) in China have ranked the
first in the world. Because of its unique biophysical and biochemical properties,
Nd compounds have entered into the agricultural environment greatly to promote
plant growth. Mitochondria play a crucial role in respiration and metabolism
during the growth of plants. However, little is known about the mechanism by
which Nd act at the mitochondrial level in plant cells. In this study, rice
mitochondrial swelling, collapsed transmembrane potential and decreased membrane
fluidity were examined to be important factors for mitochondria permeability
transition pore (mPTP) opening induced by Nd(III). The protection of cyclosporin
A (CsA) and dithiothreitol (DTT) could confirm that Nd(III) could trigger mPTP
opening. Additionally, mitochondrial membrane breakdown observed by TEM and the
release of cytochrome c (Cyt c) could also elucidate the mPTP opening from
another point of view. At last, the study showed that Nd(III) could restrain the
mitochondrial membrane lipid peroxide, so it might interact with anionic lipid
too. This detection will be conductive to the safe application of Nd compounds in
agriculture and food industry.
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