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10.1186/s12929-015-0128-0 http://scihub22266oqcxt.onion/10.1186/s12929-015-0128-0 C4380252!4380252!25885228     free     free     free       J+Biomed+Sci 2015 ; 22 (1): ä Nephropedia Template TP {{tp|p=25885228|t=2015. Heme oxygenase-1: emerging target of cancer therapy |pdf=|usr=}}{{25885228}} gab.com Text Heme oxygenase-1: emerging target of cancer therapy JO: J Biomed Sci http://www.kidney.de/pget.php?&tw=1&pmid=25885228 #FOAvip Heme oxygenase-1 (HO-1) is a rate-limiting enzyme catalyzing oxidative degradation of cellular heme to liberate free iron, carbon monoxide (CO) and biliverdin in mammalian cells. In addition to its primary role in heme catabolism, HO-1 exhibits anti-oxidative and anti-inflammatory functions via the actions of biliverdin and CO, respectively. HO-1 is highly induced in various disease states, including cancer. Several lines of evidence have supported the implication of HO-1 in carcinogenesis and tumor progression. HO-1 deficiency in normal cells enhances DNA damage and carcinogenesis. Nevertheless, HO-1 overexpression in cancer cells promotes proliferation and survival. Moreover, HO-1 induces angiogenesis through modulating expression of angiogenic factors. Although HO-1 is an endoplasmic reticulum resident protein, HO-1 nuclear localization is evident in tumor cells of cancer tissues. It has been shown that HO-1 is susceptible to proteolytic cleavage and translocates to nucleus to facilitate tumor growth and invasion independent of its enzymatic activity. HO-1 also impacts cancer progression through modulating tumor microenvironment. This review summarizes the current understanding of the protumorigenic role of HO-1 and its potential as a molecular target for cancer therapy. Twit Text FOAVip Heme oxygenase-1: emerging target of cancer therapy ????J Biomed Sci http://www.kidney.de/pget.php?&tw=1&pmid=25885228 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25885228 #FOAvip English Wikipedia <ref>{{Cite pmid|25885228}}</ref> Heme oxygenase-1: emerging target of cancer therapy #MMPMID25885228 Chau LY J Biomed Sci 2015[]; 22 (1): ä PMID25885228show ga Heme oxygenase-1 (HO-1) is a rate-limiting enzyme catalyzing oxidative degradation of cellular heme to liberate free iron, carbon monoxide (CO) and biliverdin in mammalian cells. In addition to its primary role in heme catabolism, HO-1 exhibits anti-oxidative and anti-inflammatory functions via the actions of biliverdin and CO, respectively. HO-1 is highly induced in various disease states, including cancer. Several lines of evidence have supported the implication of HO-1 in carcinogenesis and tumor progression. HO-1 deficiency in normal cells enhances DNA damage and carcinogenesis. Nevertheless, HO-1 overexpression in cancer cells promotes proliferation and survival. Moreover, HO-1 induces angiogenesis through modulating expression of angiogenic factors. Although HO-1 is an endoplasmic reticulum resident protein, HO-1 nuclear localization is evident in tumor cells of cancer tissues. It has been shown that HO-1 is susceptible to proteolytic cleavage and translocates to nucleus to facilitate tumor growth and invasion independent of its enzymatic activity. HO-1 also impacts cancer progression through modulating tumor microenvironment. This review summarizes the current understanding of the protumorigenic role of HO-1 and its potential as a molecular target for cancer therapy. äHeme oxygenase-1: emerging target of cancer therapy (epmc).pdf DeepDyve Pubget Overpricing