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10.1097/PPO.0000000000000104 http://scihub22266oqcxt.onion/10.1097/PPO.0000000000000104 C4380238!4380238!25815843     free     free     free       Cancer+J 2015 ; 21 (2): 49-55 Nephropedia Template TP {{tp|p=25815843|t=2015. Alternative Fuels for Cancer Cells |pdf=|usr=}}{{25815843}} gab.com Text Alternative Fuels for Cancer Cells JO: Cancer J http://www.kidney.de/pget.php?&tw=1&pmid=25815843 #FOAvip Tumor metabolism is significantly altered to support the various metabolic needs of tumor cells. The most prominent change is the increased tumor glycolysis that leads to increased glucose uptake and utilization. However, it has become obvious that many non-glucose nutrients, such as amino acids, lactate, acetate and macromolecules, can serve as alternative fuels for cancer cells. This knowledge reveals an unexpected flexibility and evolutionarily-conserved model in which cancer cells uptake nutrients from their external environment to fulfill their necessary energetic needs. It is possible that tumor cells have evolved the ability to utilize different carbon sources due to the limited supply of nutrient that can be driven by oncogenic mutations and tumor microenvironmental stresses. In certain cases, these factors permanently alter the tumor cells? metabolism, causing certain nutrients to become indispensable and thus creating opportunities for therapeutic intervention to eradicate tumors by their metabolic vulnerabilities. Twit Text FOAVip Alternative Fuels for Cancer Cells ????Cancer J http://www.kidney.de/pget.php?&tw=1&pmid=25815843 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25815843 #FOAvip English Wikipedia <ref>{{Cite pmid|25815843}}</ref> Alternative Fuels for Cancer Cells #MMPMID25815843 Keenan M; Chi JT Cancer J 2015[Mar]; 21 (2): 49-55 PMID25815843show ga Tumor metabolism is significantly altered to support the various metabolic needs of tumor cells. The most prominent change is the increased tumor glycolysis that leads to increased glucose uptake and utilization. However, it has become obvious that many non-glucose nutrients, such as amino acids, lactate, acetate and macromolecules, can serve as alternative fuels for cancer cells. This knowledge reveals an unexpected flexibility and evolutionarily-conserved model in which cancer cells uptake nutrients from their external environment to fulfill their necessary energetic needs. It is possible that tumor cells have evolved the ability to utilize different carbon sources due to the limited supply of nutrient that can be driven by oncogenic mutations and tumor microenvironmental stresses. In certain cases, these factors permanently alter the tumor cells? metabolism, causing certain nutrients to become indispensable and thus creating opportunities for therapeutic intervention to eradicate tumors by their metabolic vulnerabilities. äAlternative Fuels for Cancer Cells (epmc).pdf DeepDyve Pubget Overpricing