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10.1038/ncomms7660 http://scihub22266oqcxt.onion/10.1038/ncomms7660 C4380233!4380233!25818806     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2015 ; 6 (ä): 6660 Nephropedia Template TP {{tp|p=25818806|t=2015. HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus |pdf=|usr=}}{{25818806}} gab.com Text HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25818806 #FOAvip Intracellular transport of cargos, including many viruses, involves directed movement on microtubules mediated by motor proteins. While a number of viruses bind motors of opposing directionality, how they associate with and control these motors to accomplish directed movement remains poorly understood. Here we show that human immunodeficiency virus type 1 (HIV-1) associates with the kinesin-1 adaptor protein, Fasiculation and Elongation Factor zeta 1 (FEZ1). RNAi-mediated FEZ1 depletion blocks early infection, with virus particles exhibiting bidirectional motility but no net movement to the nucleus. Furthermore, both dynein and kinesin-1 motors are required for HIV-1 trafficking to the nucleus. Finally, the ability of exogenously expressed FEZ1 to promote early HIV-1 infection requires binding to kinesin-1. Our findings demonstrate that opposing motors both contribute to early HIV-1 movement and identify the kinesin-1 adaptor, FEZ1 as a capsid-associated host regulator of this process usurped by HIV-1 to accomplish net inward movement toward the nucleus. Twit Text FOAVip HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25818806 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25818806 #FOAvip English Wikipedia <ref>{{Cite pmid|25818806}}</ref> HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus #MMPMID25818806 Malikov V; da Silva ES; Jovasevic V; Bennett G; de Souza Aranha Vieira DA; Schulte B; Diaz-Griffero F; Walsh D; Naghavi MH Nat Commun 2015[]; 6 (ä): 6660 PMID25818806show ga Intracellular transport of cargos, including many viruses, involves directed movement on microtubules mediated by motor proteins. While a number of viruses bind motors of opposing directionality, how they associate with and control these motors to accomplish directed movement remains poorly understood. Here we show that human immunodeficiency virus type 1 (HIV-1) associates with the kinesin-1 adaptor protein, Fasiculation and Elongation Factor zeta 1 (FEZ1). RNAi-mediated FEZ1 depletion blocks early infection, with virus particles exhibiting bidirectional motility but no net movement to the nucleus. Furthermore, both dynein and kinesin-1 motors are required for HIV-1 trafficking to the nucleus. Finally, the ability of exogenously expressed FEZ1 to promote early HIV-1 infection requires binding to kinesin-1. Our findings demonstrate that opposing motors both contribute to early HIV-1 movement and identify the kinesin-1 adaptor, FEZ1 as a capsid-associated host regulator of this process usurped by HIV-1 to accomplish net inward movement toward the nucleus. äHIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward m(epmc).pdf DeepDyve Pubget Overpricing