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10.1038/ncomms7556 http://scihub22266oqcxt.onion/10.1038/ncomms7556 C4380165!4380165 !25766473     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25766473 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2015 ; 6 (ä): 6556 Nephropedia Template TP {{tp|p=25766473 |t=2015. Notch1-Dll4 signalling and mechanical force regulate leader cell formation during collective cell migration |pdf=|usr=}}{{25766473 }} gab.com Text Notch1-Dll4 signalling and mechanical force regulate leader cell formation during collective cell migration JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25766473 #FOAvip At the onset of collective cell migration, a subset of cells within an initially homogenous population acquires a distinct 'leader' phenotype with characteristic morphology and motility. However, the factors driving the leader cell formation as well as the mechanisms regulating leader cell density during the migration process remain to be determined. Here we use single-cell gene expression analysis and computational modelling to show that the leader cell identity is dynamically regulated by Dll4 signalling through both Notch1 and cellular stress in a migrating epithelium. Time-lapse microscopy reveals that Dll4 is induced in leader cells after the creation of the cell-free region and leader cells are regulated via Notch1-Dll4 lateral inhibition. Furthermore, mechanical stress inhibits Dll4 expression and leader cell formation in the monolayer. Collectively, our findings suggest that a reduction of mechanical force near the boundary promotes Notch1-Dll4 signalling to dynamically regulate the density of leader cells during collective cell migration. Twit Text FOAVip Notch1-Dll4 signalling and mechanical force regulate leader cell formation during collective cell migration ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25766473 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25766473 #FOAvip English Wikipedia <ref>{{Cite pmid|25766473 }}</ref> Notch1-Dll4 signalling and mechanical force regulate leader cell formation during collective cell migration #MMPMID25766473 Riahi R ; Sun J ; Wang S ; Long M ; Zhang DD ; Wong PK Nat Commun 2015[Mar]; 6 (ä): 6556 PMID25766473 show ga At the onset of collective cell migration, a subset of cells within an initially homogenous population acquires a distinct 'leader' phenotype with characteristic morphology and motility. However, the factors driving the leader cell formation as well as the mechanisms regulating leader cell density during the migration process remain to be determined. Here we use single-cell gene expression analysis and computational modelling to show that the leader cell identity is dynamically regulated by Dll4 signalling through both Notch1 and cellular stress in a migrating epithelium. Time-lapse microscopy reveals that Dll4 is induced in leader cells after the creation of the cell-free region and leader cells are regulated via Notch1-Dll4 lateral inhibition. Furthermore, mechanical stress inhibits Dll4 expression and leader cell formation in the monolayer. Collectively, our findings suggest that a reduction of mechanical force near the boundary promotes Notch1-Dll4 signalling to dynamically regulate the density of leader cells during collective cell migration. |*Cell Movement [MESH] |Adaptor Proteins, Signal Transducing [MESH] |Animals [MESH] |Calcium-Binding Proteins [MESH] |Cell Communication [MESH] |Cell Differentiation [MESH] |Coculture Techniques [MESH] |Computer Simulation [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |Intercellular Signaling Peptides and Proteins/metabolism [MESH] |Intracellular Signaling Peptides and Proteins/*metabolism [MESH] |MCF-7 Cells [MESH] |Male [MESH] |Membrane Proteins/*metabolism [MESH] |Mice [MESH] |Microscopy, Fluorescence [MESH] |RNA, Small Interfering/metabolism [MESH] |Receptor, Notch1/*metabolism [MESH] |Signal Transduction [MESH]Notch1-Dll4 signalling and mechanical force regulate leader cell forma(epmc).pdf DeepDyve Pubget Overpricing