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10.4049/jimmunol.1301284 http://scihub22266oqcxt.onion/10.4049/jimmunol.1301284 C4380085!4380085!24646739     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2014 ; 192 (8): 3607-17 Nephropedia Template TP {{tp|p=24646739|t=2014. B cell antigen presentation in the initiation of Follicular Helper T cell and Germinal Center differentiation |pdf=|usr=}}{{24646739}} gab.com Text B cell antigen presentation in the initiation of Follicular Helper T cell and Germinal Center differentiation JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24646739 #FOAvip High affinity class-switched antibodies and memory B cells are products of the germinal center. The CD4+ T cell help required for the development and maintenance of the germinal center is delivered by follicular helper T cells (TFH), a CD4+ helper T cell subset characterized by expression of Bcl-6 and secretion of IL-21. The cellular interactions that mediate differentiation of TFH and GC B cells remain an important area of investigation. We previously showed that MHC class II-dependent DC antigen presentation is sufficient for the differentiation of a TFH intermediate (termed pre-TFH), characterized by Bcl-6 expression but lacking IL-21 secretion. Here we examine the contributions of MHCII antigen presentation by B cells to TFH differentiation and GC responses in several contexts. B cells alone do not efficiently prime naïve CD4+ T cells or induce TFH following protein immunization; however, during LCMV infection B cells induce TFH differentiation despite the lack of effector CD4+ T cell generation. Still, MHCII-positive DCs and B cells cooperate for optimal TFH and GC B cell differentiation in response to both model antigens and viral infection. This study highlights the roles for B cells in both CD4+ T cell priming and TFH differentiation and demonstrates that different APC subsets work in tandem to mediate the germinal center response. Twit Text FOAVip B cell antigen presentation in the initiation of Follicular Helper T cell and Germinal Center differentiation ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24646739 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24646739 #FOAvip English Wikipedia <ref>{{Cite pmid|24646739}}</ref> B cell antigen presentation in the initiation of Follicular Helper T cell and Germinal Center differentiation #MMPMID24646739 Barnett LG; Simkins HM; Barnett BE; Korn LL; Johnson AL; Wherry EJ; Wu GF; Laufer TM J Immunol 2014[Apr]; 192 (8): 3607-17 PMID24646739show ga High affinity class-switched antibodies and memory B cells are products of the germinal center. The CD4+ T cell help required for the development and maintenance of the germinal center is delivered by follicular helper T cells (TFH), a CD4+ helper T cell subset characterized by expression of Bcl-6 and secretion of IL-21. The cellular interactions that mediate differentiation of TFH and GC B cells remain an important area of investigation. We previously showed that MHC class II-dependent DC antigen presentation is sufficient for the differentiation of a TFH intermediate (termed pre-TFH), characterized by Bcl-6 expression but lacking IL-21 secretion. Here we examine the contributions of MHCII antigen presentation by B cells to TFH differentiation and GC responses in several contexts. B cells alone do not efficiently prime naïve CD4+ T cells or induce TFH following protein immunization; however, during LCMV infection B cells induce TFH differentiation despite the lack of effector CD4+ T cell generation. Still, MHCII-positive DCs and B cells cooperate for optimal TFH and GC B cell differentiation in response to both model antigens and viral infection. This study highlights the roles for B cells in both CD4+ T cell priming and TFH differentiation and demonstrates that different APC subsets work in tandem to mediate the germinal center response. äB cell antigen presentation in the initiation of Follicular Helper T c(epmc).pdf DeepDyve Pubget Overpricing