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10.1242/jcs.165472 http://scihub22266oqcxt.onion/10.1242/jcs.165472 C4379730!4379730 !25663703     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25663703 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Sci 2015 ; 128 (7 ): 1434-43 Nephropedia Template TP {{tp|p=25663703 |t=2015. The multivesicular body is the major internal site of prion conversion |pdf=|usr=}}{{25663703 }} gab.com Text The multivesicular body is the major internal site of prion conversion JO: J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=25663703 #FOAvip The conversion of the properly folded prion protein, PrPc, to its misfolded amyloid form, PrPsc, occurs as the two proteins traffic along the endocytic pathway and PrPc is exposed to PrPsc. To determine the specific site of prion conversion, we knocked down various proteins in the endocytic pathway including Rab7a, Tsg101 and Hrs (also known as HGS). PrPsc was markedly reduced in two chronically infected cell lines by preventing the maturation of the multivesicular body, a process that begins in the early endosome and ends with the sorting of cargo to the lysosome. By contrast, knocking down proteins in the retromer complex, which diverts cargo away from the multivesicular body caused an increase in PrPsc levels. These results suggest that the multivesicular body is the major site for intracellular conversion of PrPc to PrPsc. Twit Text FOAVip The multivesicular body is the major internal site of prion conversion ????J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=25663703 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25663703 #FOAvip English Wikipedia <ref>{{Cite pmid|25663703 }}</ref> The multivesicular body is the major internal site of prion conversion #MMPMID25663703 Yim YI ; Park BC ; Yadavalli R ; Zhao X ; Eisenberg E ; Greene LE J Cell Sci 2015[Apr]; 128 (7 ): 1434-43 PMID25663703 show ga The conversion of the properly folded prion protein, PrPc, to its misfolded amyloid form, PrPsc, occurs as the two proteins traffic along the endocytic pathway and PrPc is exposed to PrPsc. To determine the specific site of prion conversion, we knocked down various proteins in the endocytic pathway including Rab7a, Tsg101 and Hrs (also known as HGS). PrPsc was markedly reduced in two chronically infected cell lines by preventing the maturation of the multivesicular body, a process that begins in the early endosome and ends with the sorting of cargo to the lysosome. By contrast, knocking down proteins in the retromer complex, which diverts cargo away from the multivesicular body caused an increase in PrPsc levels. These results suggest that the multivesicular body is the major site for intracellular conversion of PrPc to PrPsc. |Animals [MESH] |Brain/metabolism [MESH] |Lysosomes/metabolism [MESH] |Mice [MESH] |Multivesicular Bodies/*metabolism [MESH] |PrPC Proteins/genetics/metabolism [MESH] |PrPSc Proteins/genetics/metabolism [MESH] |Prions/genetics/*metabolism [MESH]The multivesicular body is the major internal site of prion conversion(epmc).pdf DeepDyve Pubget Overpricing